SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2mqs MATRIX
METALLOPROTEINASE-14
THP_L_AND_M_CHAIN
(;
Homo
sapiens) 		4 / 7 GLY A 352
GLY B  15
PHE A 360
PHE A 341
 None
 0.87A 2qwxA-2mqsA:
undetectable
2qwxB-2mqsA:
undetectable		 2qwxA-2mqsA:
22.17
2qwxB-2mqsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 6 TYR A 435
PHE A 430
PHE A 477
PHE A 486
 None
 1.49A 3af3A-2mqsA:
undetectable		 3af3A-2mqsA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 LEU A 329
TRP A 388
TYR A 372
 None
 0.98A 3aicA-2mqsA:
undetectable		 3aicA-2mqsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 LEU A 329
TRP A 388
TYR A 372
 None
 1.01A 3aicB-2mqsA:
undetectable		 3aicB-2mqsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 LEU A 329
TRP A 388
TYR A 372
 None
 1.01A 3aicE-2mqsA:
undetectable		 3aicE-2mqsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		3 / 3 LEU A 329
TRP A 388
TYR A 372
 None
 0.97A 3aicF-2mqsA:
undetectable		 3aicF-2mqsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 8 GLY A 352
PHE A 390
PHE A 381
PHE A 336
 None
 1.08A 3ko0D-2mqsA:
undetectable
3ko0E-2mqsA:
undetectable		 3ko0D-2mqsA:
24.71
3ko0E-2mqsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 7 GLY A 352
PHE A 390
PHE A 381
PHE A 336
 None
 1.04A 3ko0L-2mqsA:
undetectable
3ko0N-2mqsA:
undetectable		 3ko0L-2mqsA:
24.71
3ko0N-2mqsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 7 PHE A 336
GLY A 352
PHE A 390
PHE A 381
 None
 1.08A 3ko0K-2mqsA:
undetectable
3ko0S-2mqsA:
undetectable		 3ko0K-2mqsA:
24.71
3ko0S-2mqsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2mqs MATRIX
METALLOPROTEINASE-14
(Homo
sapiens) 		4 / 7 PHE A 336
GLY A 352
PHE A 390
PHE A 381
 None
 0.95A 3ko0R-2mqsA:
undetectable
3ko0T-2mqsA:
undetectable		 3ko0R-2mqsA:
24.71
3ko0T-2mqsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2mqs MATRIX
METALLOPROTEINASE-14
THP_L_AND_M_CHAIN
(;
Homo
sapiens) 		5 / 12 TRP A 361
ALA A 393
ILE B  13
GLU A 392
GLY B  15
 None
 1.24A 4hfpB-2mqsA:
undetectable		 4hfpB-2mqsA:
22.10