SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2mqw 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  11
ILE A  10
LEU A  41
VAL A  66
LEU A  61
 None
 1.24A 1e7aB-2mqwA:
undetectable		 1e7aB-2mqwA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2mqw 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 106
LEU A 102
ASN A  74
ILE A  73
 None
 0.93A 1yc2E-2mqwA:
undetectable		 1yc2E-2mqwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2mqw 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  26
THR A  13
ASP A   8
GLU A  30
 None
 1.23A 5ybbA-2mqwA:
undetectable		 5ybbA-2mqwA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2mqw 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  41
GLN A  40
PHE A  39
PHE A   2
 None
 1.33A 6nmpP-2mqwA:
2.9
6nmpW-2mqwA:
undetectable		 6nmpP-2mqwA:
20.00
6nmpW-2mqwA:
17.61