SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2mra DE NOVO DESIGNED
PROTEIN OR459
(synthetic
construct) 		4 / 6 LEU A 110
LYS A  91
ALA A  85
HIS A 112
 None
 1.36A 3gv1A-2mraA:
undetectable
3gv1B-2mraA:
undetectable		 3gv1A-2mraA:
23.65
3gv1B-2mraA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2mra DE NOVO DESIGNED
PROTEIN OR459
(synthetic
construct) 		5 / 11 ALA A  41
ALA A  44
VAL A  56
LEU A  25
TRP A  76
 None
 1.08A 5eb5A-2mraA:
undetectable		 5eb5A-2mraA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2mra DE NOVO DESIGNED
PROTEIN OR459
(synthetic
construct) 		5 / 10 ALA A  41
ALA A  44
VAL A  56
LEU A  25
TRP A  76
 None
 1.10A 5eb5B-2mraA:
undetectable		 5eb5B-2mraA:
11.53