SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 258
LEU A 255
ALA A 221
MET A 239
 None
 1.05A 2wekA-2mriA:
undetectable		 2wekA-2mriA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 334
LEU A 327
ILE A 350
VAL A 348
 None
 0.86A 4ojbA-2mriA:
undetectable		 4ojbA-2mriA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 194
LEU A 233
ASN A 186
 None
 0.67A 4otwA-2mriA:
undetectable		 4otwA-2mriA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 217
LEU A 258
ASN A 229
 None
 0.69A 4otwA-2mriA:
undetectable		 4otwA-2mriA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 195
THR A 191
THR A 198
 None
 0.78A 5aoxB-2mriA:
undetectable		 5aoxB-2mriA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 195
THR A 191
THR A 198
 None
 0.80A 5aoxE-2mriA:
undetectable		 5aoxE-2mriA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 235
GLU A 232
LEU A 222
TYR A 228
 None
 1.09A 5igiA-2mriA:
2.7		 5igiA-2mriA:
20.26