SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	5 / 12	PHE A 35 PRO A 71 VAL A 68 ALA A 18 LEU A 52	None	1.24A	2x2nC-2mvuA: undetectable	2x2nC-2mvuA: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	4 / 8	LEU A 26 SER A 27 LEU A 75 ILE A 38	None	0.92A	3ln1A-2mvuA: undetectable	3ln1A-2mvuA: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	4 / 7	LEU A 26 SER A 27 LEU A 75 ILE A 38	None	0.93A	3ln1B-2mvuA: undetectable	3ln1B-2mvuA: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA603_1 (SERUM ALBUMIN)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	5 / 11	ARG A 72 LEU A 75 LEU A 4 LEU A 31 LEU A 5	None	1.25A	4or0A-2mvuA: undetectable	4or0A-2mvuA: 9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_B_NPSB603_1 (SERUM ALBUMIN)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	5 / 11	ARG A 72 LEU A 75 LEU A 4 LEU A 31 LEU A 5	None	1.25A	4or0B-2mvuA: undetectable	4or0B-2mvuA: 9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YIA_B_IMNB401_1 (THYROXINE-BINDING GLOBULIN)	2mvu	ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces coelicolor)	5 / 10	LEU A 77 LEU A 74 SER A 42 LEU A 45 LEU A 52	None None SDO A 101 (-1.5A) None None	1.18A	4yiaA-2mvuA: undetectable	4yiaA-2mvuA: 14.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X2N_C_X2NC1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",5,"PHE A  35;PRO A  71;VAL A  68;ALA A  18;LEU A  52","None","1.24A","2x2nC-2mvuA:undetectable","2x2nC-2mvuA:10.75"],["3LN1_A_CELA682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",4,"LEU A  26;SER A  27;LEU A  75;ILE A  38","None","0.92A","3ln1A-2mvuA:undetectable","3ln1A-2mvuA:10.67"],["3LN1_B_CELB682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",4,"LEU A  26;SER A  27;LEU A  75;ILE A  38","None","0.93A","3ln1B-2mvuA:undetectable","3ln1B-2mvuA:10.67"],["4OR0_A_NPSA603_1","SERUM ALBUMIN","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",5,"ARG A  72;LEU A  75;LEU A   4;LEU A  31;LEU A   5","None","1.25A","4or0A-2mvuA:undetectable","4or0A-2mvuA:9.95"],["4OR0_B_NPSB603_1","SERUM ALBUMIN","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",5,"ARG A  72;LEU A  75;LEU A   4;LEU A  31;LEU A   5","None","1.25A","4or0B-2mvuA:undetectable","4or0B-2mvuA:9.95"],["4YIA_B_IMNB401_1","THYROXINE-BINDING GLOBULIN;THYROXINE-BINDING GLOBULIN","2mvu","ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces coelicolor",5,"LEU A  77;LEU A  74;SER A  42;LEU A  45;LEU A  52","None;None;SDO A 101 (-1.5A);None;None","1.18A","4yiaA-2mvuA:undetectable","4yiaA-2mvuA:14.79"]]