SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN
(Lactobacillus
acidophilus) 		5 / 10 PRO A  94
LEU A  98
ILE A  82
SER A  12
GLY A  83
 None
 1.41A 3ijxB-2mwmA:
undetectable
3ijxD-2mwmA:
undetectable		 3ijxB-2mwmA:
22.39
3ijxD-2mwmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN
(Lactobacillus
acidophilus) 		5 / 10 PRO A  94
LEU A  98
ILE A  82
SER A  12
GLY A  83
 None
 1.36A 3iluB-2mwmA:
undetectable
3iluE-2mwmA:
undetectable		 3iluB-2mwmA:
22.39
3iluE-2mwmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN
(Lactobacillus
acidophilus) 		5 / 11 ILE A  82
SER A  12
GLY A  83
PRO A  94
LEU A  98
 None
 1.35A 3iluB-2mwmA:
undetectable
3iluE-2mwmA:
undetectable		 3iluB-2mwmA:
22.39
3iluE-2mwmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN
(Lactobacillus
acidophilus) 		5 / 12 ILE A  24
ALA A 110
LEU A  81
LEU A  79
ILE A 137
 None
 1.05A 3uvvA-2mwmA:
undetectable		 3uvvA-2mwmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN
(Lactobacillus
acidophilus) 		4 / 6 SER A  14
ALA A  45
THR A  50
ALA A  92
 None
 1.03A 6ma6A-2mwmA:
undetectable		 6ma6A-2mwmA:
19.48