SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 7 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 1.00A 1rxcC-2mx6A:
undetectable		 1rxcC-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 7 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.94A 1rxcD-2mx6A:
undetectable		 1rxcD-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.98A 1rxcE-2mx6A:
undetectable		 1rxcE-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 7 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.97A 1rxcF-2mx6A:
undetectable		 1rxcF-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 7 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 1rxcL-2mx6A:
undetectable		 1rxcL-2mx6A:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		9 / 11 PHE A 261
LEU A 262
GLY A 263
ILE A 264
ILE A 266
MET A 284
VAL A 318
LEU A 321
VAL A 325
 None
 0.65A 2kawA-2mx6A:
19.6		 2kawA-2mx6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		8 / 11 PHE A 261
LEU A 262
GLY A 263
ILE A 264
SER A 265
ILE A 266
LEU A 321
VAL A 325
 None
 0.69A 2kawA-2mx6A:
19.6		 2kawA-2mx6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		5 / 11 ALA A 288
VAL A 252
GLY A 263
ILE A 264
VAL A 335
 None
 1.18A 2uxpB-2mx6A:
undetectable		 2uxpB-2mx6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		5 / 11 ALA A 291
VAL A 252
GLY A 263
ILE A 264
VAL A 335
 None
 1.22A 2uxpB-2mx6A:
undetectable		 2uxpB-2mx6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 3kvvA-2mx6A:
undetectable		 3kvvA-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 3kvvB-2mx6A:
undetectable		 3kvvB-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.97A 3kvvC-2mx6A:
undetectable		 3kvvC-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 3kvvD-2mx6A:
undetectable		 3kvvD-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.95A 3kvvE-2mx6A:
undetectable		 3kvvE-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 3kvvF-2mx6A:
undetectable		 3kvvF-2mx6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 4e1vA-2mx6A:
undetectable		 4e1vA-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 7 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 1.00A 4e1vB-2mx6A:
undetectable		 4e1vB-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.95A 4e1vC-2mx6A:
undetectable		 4e1vC-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.96A 4e1vD-2mx6A:
undetectable		 4e1vD-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.99A 4e1vE-2mx6A:
undetectable		 4e1vE-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 6 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.97A 4e1vF-2mx6A:
undetectable		 4e1vF-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 0.97A 4e1vG-2mx6A:
undetectable		 4e1vG-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		4 / 8 GLY A 281
MET A 284
ILE A 266
VAL A 267
 None
 1.00A 4e1vH-2mx6A:
undetectable		 4e1vH-2mx6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2mx6 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1
(Mus
musculus) 		5 / 12 ILE A 266
GLY A 277
GLY A 268
ALA A 317
MET A 300
 None
 1.12A 4kicB-2mx6A:
undetectable		 4kicB-2mx6A:
13.35