SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	2mxz	L-ALANYL-D-GLUTAMATE PEPTIDASE (Escherichia virus T5)	5 / 12	PHE A 5 LEU A 108 PHE A 35 PHE A 110 ALA A 96	None	1.02A	1fe2A-2mxzA: undetectable	1fe2A-2mxzA: 13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_A_CTXA1_1 (CES1 PROTEIN)	2mxz	L-ALANYL-D-GLUTAMATE PEPTIDASE (Escherichia virus T5)	5 / 12	ALA A 71 PHE A 74 GLY A 132 GLY A 131 LEU A 108	None	0.98A	1ya4A-2mxzA: undetectable	1ya4A-2mxzA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RV5_A_DXCA92_0 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	2mxz	L-ALANYL-D-GLUTAMATE PEPTIDASE (Escherichia virus T5)	4 / 4	LYS A 4 PHE A 3 PHE A 74 VAL A 93	None	1.29A	3rv5A-2mxzA: 0.6 3rv5B-2mxzA: undetectable	3rv5A-2mxzA: 21.23 3rv5B-2mxzA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_B_SAMB303_0 (METHYLTRANSFERASE)	2mxz	L-ALANYL-D-GLUTAMATE PEPTIDASE (Escherichia virus T5)	5 / 12	LEU A 30 VAL A 93 TYR A 33 PHE A 74 ALA A 24	None	1.07A	5n5dB-2mxzA: undetectable	5n5dB-2mxzA: 24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EMU_A_SAMA501_0 (TRNA (GUANINE(9)-/ADENINE (9)-N1)-METHYLTRANSF ERASE)	2mxz	L-ALANYL-D-GLUTAMATE PEPTIDASE (Escherichia virus T5)	5 / 12	PRO A 18 ILE A 41 GLY A 40 ILE A 72 ASP A 70	None	1.01A	6emuA-2mxzA: undetectable	6emuA-2mxzA: 23.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FE2_A_LAXA700_2","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","2mxz","L-ALANYL-D-GLUTAMATE PEPTIDASE","Escherichia virus T5",5,"PHE A   5;LEU A 108;PHE A  35;PHE A 110;ALA A  96","None","1.02A","1fe2A-2mxzA:undetectable","1fe2A-2mxzA:13.46"],["1YA4_A_CTXA1_1","CES1 PROTEIN","2mxz","L-ALANYL-D-GLUTAMATE PEPTIDASE","Escherichia virus T5",5,"ALA A  71;PHE A  74;GLY A 132;GLY A 131;LEU A 108","None","0.98A","1ya4A-2mxzA:undetectable","1ya4A-2mxzA:13.58"],["3RV5_A_DXCA92_0","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","2mxz","L-ALANYL-D-GLUTAMATE PEPTIDASE","Escherichia virus T5",4,"LYS A   4;PHE A   3;PHE A  74;VAL A  93","None","1.29A","3rv5A-2mxzA:0.6;3rv5B-2mxzA:undetectable","3rv5A-2mxzA:21.23;3rv5B-2mxzA:21.23"],["5N5D_B_SAMB303_0","METHYLTRANSFERASE","2mxz","L-ALANYL-D-GLUTAMATE PEPTIDASE","Escherichia virus T5",5,"LEU A  30;VAL A  93;TYR A  33;PHE A  74;ALA A  24","None","1.07A","5n5dB-2mxzA:undetectable","5n5dB-2mxzA:24.43"],["6EMU_A_SAMA501_0","TRNA (GUANINE(9)-\/ADENINE(9)-N1)-METHYLTRANSFERASE","2mxz","L-ALANYL-D-GLUTAMATE PEPTIDASE","Escherichia virus T5",5,"PRO A  18;ILE A  41;GLY A  40;ILE A  72;ASP A  70","None","1.01A","6emuA-2mxzA:undetectable","6emuA-2mxzA:23.50"]]