SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2myi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 5 LEU A 125
TYR A  94
GLN A  96
TYR A 145
 None
 1.30A 1yc2B-2myiA:
undetectable
1yc2C-2myiA:
undetectable		 1yc2B-2myiA:
21.96
1yc2C-2myiA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		5 / 11 GLN A  34
LEU A  50
ALA A  69
LEU A  70
SER A  72
 None
 1.36A 2c12F-2myiA:
undetectable		 2c12F-2myiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		3 / 3 ARG A 192
GLU A 193
GLN A 153
 None
 1.07A 2p16A-2myiA:
undetectable		 2p16A-2myiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		5 / 12 TYR A 253
LEU A 228
VAL A 102
LEU A 249
LEU A 191
 None
 1.46A 2prgB-2myiA:
undetectable		 2prgB-2myiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 7 TYR A 132
TYR A 145
TYR A 143
ILE A 181
 None
 1.34A 2xz5B-2myiA:
undetectable
2xz5E-2myiA:
undetectable		 2xz5B-2myiA:
18.96
2xz5E-2myiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 7 ILE A 181
TYR A 132
TYR A 145
TYR A 143
 None
 1.35A 2xz5D-2myiA:
undetectable
2xz5E-2myiA:
undetectable		 2xz5D-2myiA:
18.96
2xz5E-2myiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 5 TYR A  48
ILE A  11
LEU A  23
LEU A  20
 None
 1.17A 2zb7A-2myiA:
undetectable		 2zb7A-2myiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 8 ARG A  37
PRO A 110
SER A 148
GLY A  66
 None
 1.01A 3hcrA-2myiA:
undetectable		 3hcrA-2myiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 7 ARG A  37
PRO A 110
SER A 148
GLY A  66
 None
 0.98A 3hcrB-2myiA:
undetectable		 3hcrB-2myiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		3 / 3 ALA A 176
ARG A 175
LYS A 155
 None
 0.94A 3kp3B-2myiA:
undetectable		 3kp3B-2myiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		5 / 12 CYH A 146
ILE A 144
ARG A 233
ASP A 252
LEU A 237
 None
 1.00A 3uj6A-2myiA:
undetectable		 3uj6A-2myiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 8 LEU A  23
LEU A  20
ILE A  31
VAL A   8
 None
 0.88A 4klaA-2myiA:
undetectable		 4klaA-2myiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		3 / 3 ASP A 128
LEU A 125
PHE A 129
 None
 0.71A 4pthA-2myiA:
undetectable		 4pthA-2myiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		4 / 6 LEU A 108
ALA A  69
LEU A  33
SER A   5
 None
 1.26A 5l4iB-2myiA:
undetectable		 5l4iB-2myiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		3 / 3 SER A  72
TYR A  71
TYR A  53
 None
 0.90A 5lakA-2myiA:
undetectable
5lakI-2myiA:
undetectable		 5lakA-2myiA:
20.19
5lakI-2myiA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		3 / 3 SER A  72
TYR A  71
TYR A  53
 None
 0.82A 5lakC-2myiA:
undetectable
5lakJ-2myiA:
undetectable		 5lakC-2myiA:
20.19
5lakJ-2myiA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2myi EXODEOXYRIBONUCLEASE
III
(Pseudomonas
sp.
Lz4W) 		5 / 12 LEU A 107
GLY A 147
SER A  72
ASP A  29
CYH A  32
 None
 1.32A 6bxlA-2myiA:
undetectable		 6bxlA-2myiA:
21.45