SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  24
GLY A  26
ILE A   5
PRO A  36
LEU A  37
 None
 1.09A 3eeoA-2mzbA:
undetectable		 3eeoA-2mzbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A  48
ASP A  83
LEU A  84
PHE A  95
THR A  75
 None
 1.11A 3freX-2mzbA:
2.1		 3freX-2mzbA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 4 PRO A  51
THR A  53
GLY A  11
THR A  12
 None
 1.13A 3ib1A-2mzbA:
undetectable		 3ib1A-2mzbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  21
GLY A   8
ALA A   7
VAL A  72
ILE A  30
 None
 0.83A 3oxvC-2mzbA:
undetectable		 3oxvC-2mzbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 183
LEU A  24
VAL A  33
 None
 0.71A 4jecB-2mzbA:
undetectable		 4jecB-2mzbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  14
ASP A 183
PHE A 176
 None
 0.94A 4xeyA-2mzbA:
undetectable		 4xeyA-2mzbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  14
ASP A 183
PHE A 176
 None
 0.98A 4xeyB-2mzbA:
undetectable		 4xeyB-2mzbA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  56
THR A  75
LEU A   4
 None
 0.56A 5m66D-2mzbA:
2.4		 5m66D-2mzbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A   5
ILE A  30
LEU A  29
ILE A 154
ASN A 155
 None
 1.21A 5vkqA-2mzbA:
undetectable
5vkqD-2mzbA:
undetectable		 5vkqA-2mzbA:
8.24
5vkqD-2mzbA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 154
ASN A 155
ILE A   5
ILE A  30
LEU A  29
 None
 1.20A 5vkqA-2mzbA:
undetectable
5vkqB-2mzbA:
undetectable		 5vkqA-2mzbA:
8.24
5vkqB-2mzbA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 154
ASN A 155
ILE A   5
ILE A  30
LEU A  29
 None
 1.20A 5vkqC-2mzbA:
undetectable
5vkqD-2mzbA:
undetectable		 5vkqC-2mzbA:
8.24
5vkqD-2mzbA:
8.24