SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F7F_A_NIOA601_1 (NICOTINATE PHOSPHORIBOSYLTRANSF ERASE, PUTATIVE)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 6	SER A 381 GLY A 417 THR A 416 ARG A 408	None	1.05A	2f7fA-2mztA: undetectable	2f7fA-2mztA: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F3T_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 4	PHE A 364 VAL A 420 ALA A 405 PHE A 396	None	1.45A	4f3tA-2mztA: 2.7	4f3tA-2mztA: 8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5Q_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 4	PHE A 364 VAL A 420 ALA A 405 PHE A 396	None	1.46A	4w5qA-2mztA: 2.4	4w5qA-2mztA: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 4	PHE A 364 VAL A 420 ALA A 405 PHE A 396	None	1.47A	4z4gA-2mztA: 2.9	4z4gA-2mztA: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KI6_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 4	PHE A 364 VAL A 420 ALA A 405 PHE A 396	None	1.48A	5ki6A-2mztA: 2.8	5ki6A-2mztA: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VC0_A_RITA602_2 (CYTOCHROME P450 3A4)	2mzt	PROTEIN HRB1 (Saccharomyces cerevisiae)	4 / 7	ILE A 448 LEU A 392 THR A 416 ARG A 453	None	1.03A	5vc0A-2mztA: undetectable	5vc0A-2mztA: 11.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2F7F_A_NIOA601_1","NICOTINATE PHOSPHORIBOSYLTRANSFERASE, PUTATIVE","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"SER A 381;GLY A 417;THR A 416;ARG A 408","None","1.05A","2f7fA-2mztA:undetectable","2f7fA-2mztA:12.53"],["4F3T_A_IPHA901_0","PROTEIN ARGONAUTE-2","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"PHE A 364;VAL A 420;ALA A 405;PHE A 396","None","1.45A","4f3tA-2mztA:2.7","4f3tA-2mztA:8.18"],["4W5Q_A_IPHA904_0","PROTEIN ARGONAUTE-2","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"PHE A 364;VAL A 420;ALA A 405;PHE A 396","None","1.46A","4w5qA-2mztA:2.4","4w5qA-2mztA:8.22"],["4Z4G_A_IPHA904_0","PROTEIN ARGONAUTE-2","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"PHE A 364;VAL A 420;ALA A 405;PHE A 396","None","1.47A","4z4gA-2mztA:2.9","4z4gA-2mztA:8.22"],["5KI6_A_IPHA902_0","PROTEIN ARGONAUTE-2","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"PHE A 364;VAL A 420;ALA A 405;PHE A 396","None","1.48A","5ki6A-2mztA:2.8","5ki6A-2mztA:8.22"],["5VC0_A_RITA602_2","CYTOCHROME P450 3A4","2mzt","PROTEIN HRB1","Saccharomyces cerevisiae",4,"ILE A 448;LEU A 392;THR A 416;ARG A 453","None","1.03A","5vc0A-2mztA:undetectable","5vc0A-2mztA:11.23"]]