SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2mzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		5 / 11 GLN A 431
ALA A 439
LEU A 461
VAL A 462
MET A 465
 None
 1.21A 2c12B-2mzwA:
undetectable		 2c12B-2mzwA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		5 / 10 TYR A 668
GLY A 653
ALA A 655
TYR A 482
VAL A 480
 None
 1.49A 2coiA-2mzwA:
undetectable
2coiB-2mzwA:
undetectable		 2coiA-2mzwA:
21.55
2coiB-2mzwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 6 GLU A 610
ARG A 665
THR A 662
ALA A 639
 None
 1.17A 3ns1C-2mzwA:
undetectable		 3ns1C-2mzwA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 7 ILE A 682
ARG A 627
VAL A 646
MET A 670
 None
 1.45A 4f4dA-2mzwA:
undetectable		 4f4dA-2mzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 8 ILE A 682
ARG A 627
VAL A 646
MET A 670
 None
 1.31A 4f4dB-2mzwA:
undetectable		 4f4dB-2mzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 8 GLU A 517
GLU A 484
TYR A 557
TYR A 671
 None
 1.17A 4mj8A-2mzwA:
undetectable
4mj8C-2mzwA:
undetectable		 4mj8A-2mzwA:
20.00
4mj8C-2mzwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 5 ILE A 687
LEU A 601
ASP A 597
VAL A 562
 None
 1.06A 4nkxB-2mzwA:
undetectable		 4nkxB-2mzwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		4 / 8 ARG A 659
ALA A 655
LEU A 658
GLY A 666
 None
 0.91A 4xk8a-2mzwA:
undetectable		 4xk8a-2mzwA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		5 / 12 ASP A 561
ALA A 555
ASP A 442
SER A 481
TYR A 482
 None
 1.24A 5hfjE-2mzwA:
undetectable		 5hfjE-2mzwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2mzw ELONGATION FACTOR G
(Staphylococcus
aureus) 		3 / 3 ARG A 665
PRO A 612
ASN A 638
 None
 1.07A 5jwaA-2mzwA:
undetectable
5jwaH-2mzwA:
undetectable		 5jwaA-2mzwA:
18.34
5jwaH-2mzwA:
18.34