SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 8 HIS A4401
SER A4400
HIS A4395
TYR A4517
 None
 1.32A 1eqbA-2n03A:
undetectable
1eqbB-2n03A:
undetectable		 1eqbA-2n03A:
19.19
1eqbB-2n03A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A4517
HIS A4401
SER A4400
HIS A4395
 None
 1.31A 1eqbA-2n03A:
undetectable
1eqbB-2n03A:
undetectable		 1eqbA-2n03A:
19.19
1eqbB-2n03A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 8 HIS A4401
SER A4400
HIS A4395
TYR A4517
 None
 1.31A 1eqbC-2n03A:
undetectable
1eqbD-2n03A:
undetectable		 1eqbC-2n03A:
19.19
1eqbD-2n03A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A4517
HIS A4401
SER A4400
HIS A4395
 None
 1.31A 1eqbC-2n03A:
undetectable
1eqbD-2n03A:
undetectable		 1eqbC-2n03A:
19.19
1eqbD-2n03A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A4517
HIS A4401
SER A4400
HIS A4395
 None
 1.33A 2vmyA-2n03A:
undetectable
2vmyB-2n03A:
undetectable		 2vmyA-2n03A:
20.40
2vmyB-2n03A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2n03 PLECTIN
(Homo
sapiens) 		5 / 12 ASP A4555
LEU A4516
GLY A4514
ALA A4508
ALA A4507
 None
 1.07A 3sufA-2n03A:
undetectable		 3sufA-2n03A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2n03 PLECTIN
(Homo
sapiens) 		4 / 7 LEU A4449
ALA A4472
ASP A4471
VAL A4483
 None
 0.90A 4eyrA-2n03A:
undetectable		 4eyrA-2n03A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2n03 PLECTIN
(Homo
sapiens) 		3 / 3 GLU A4450
ARG A4447
HIS A4394
 None
 0.84A 4kf9A-2n03A:
undetectable		 4kf9A-2n03A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2n03 PLECTIN
(Homo
sapiens) 		5 / 12 ILE A4535
GLY A4456
CYH A4454
PHE A4496
LEU A4534
 None
 1.16A 5hw4A-2n03A:
undetectable		 5hw4A-2n03A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2n03 PLECTIN
(Homo
sapiens) 		5 / 12 ILE A4535
GLY A4456
CYH A4454
PHE A4496
LEU A4534
 None
 1.15A 5hw4C-2n03A:
undetectable		 5hw4C-2n03A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2n03 PLECTIN
(Homo
sapiens) 		5 / 9 ASN A4442
ILE A4486
VAL A4469
ILE A4458
MET A4435
 None
 1.43A 6hloA-2n03A:
undetectable		 6hloA-2n03A:
17.08