SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 TRP A  64
LEU A  15
LYS A  23
 None
 1.39A 1yajK-2n1bA:
2.4		 1yajK-2n1bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 TRP A 104
THR A  66
TYR A  79
 None
 1.16A 2a3aA-2n1bA:
undetectable		 2a3aA-2n1bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 TRP A 104
THR A  66
TYR A  79
 None
 1.22A 2a3aB-2n1bA:
undetectable		 2a3aB-2n1bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 TRP A 104
THR A  66
TYR A  79
 None
 1.19A 2a3bA-2n1bA:
3.6		 2a3bA-2n1bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 5 ALA A 151
ASP A 148
ASP A 200
ASP A 125
 None
 0.90A 2nyuB-2n1bA:
undetectable		 2nyuB-2n1bA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 GLY A  20
ASP A  91
SER A  94
 None
 0.67A 3brfA-2n1bA:
undetectable		 3brfA-2n1bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		5 / 8 ASP A  18
GLY A  19
GLY A  74
LEU A  75
VAL A 101
 None
 1.45A 3em6A-2n1bA:
undetectable		 3em6A-2n1bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 6 GLU A   6
ARG A  56
ALA A   3
ALA A   2
 None
 1.04A 3ns1C-2n1bA:
undetectable		 3ns1C-2n1bA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 7 ASN A 122
ALA A 151
SER A 150
VAL A 187
 None
 1.15A 4ijiH-2n1bA:
undetectable		 4ijiH-2n1bA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 5 HIS A  48
VAL A  47
VAL A  27
LYS A  28
 None
 1.36A 4p6vB-2n1bA:
undetectable
4p6vE-2n1bA:
undetectable		 4p6vB-2n1bA:
20.05
4p6vE-2n1bA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		5 / 12 ASN A 122
ASP A  91
VAL A  92
THR A  93
ALA A 194
 None
 0.86A 5kocA-2n1bA:
undetectable		 5kocA-2n1bA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2n1b GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		5 / 12 ASN A 122
ASP A  91
VAL A  92
THR A  93
ALA A 194
 None
 1.03A 5kpcB-2n1bA:
undetectable		 5kpcB-2n1bA:
29.19