SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		3 / 3 GLY B 659
GLU B 663
ASN B 656
 None
 0.61A 1zq9A-2n2hB:
undetectable		 1zq9A-2n2hB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 VAL B 633
ILE B 673
LEU B 685
VAL B 693
LEU B 658
 None
 0.93A 3gwxA-2n2hB:
undetectable		 3gwxA-2n2hB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
SIN3 HISTONE
DEACETYLASE
COREPRESSOR COMPLEX
COMPONENT SDS3
(Mus
musculus) 		4 / 5 GLU B 616
GLU B 619
PHE B 714
TYR A 209
 None
 1.37A 4a97J-2n2hB:
undetectable		 4a97J-2n2hB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		4 / 6 LEU B 685
LEU B 670
ILE B 673
THR B 630
 None
 0.78A 4do3B-2n2hB:
undetectable		 4do3B-2n2hB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		6 / 10 ILE B 682
VAL B 633
ALA B 636
LEU B 658
LEU B 654
LEU B 670
 None
 1.44A 6f6nA-2n2hB:
undetectable
6f6nB-2n2hB:
undetectable		 6f6nA-2n2hB:
23.33
6f6nB-2n2hB:
25.51