SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		4 / 7 SER A  73
PHE A  70
ALA A  75
PHE A 122
 None
 1.11A 1fxvA-2n3eA:
undetectable
1fxvB-2n3eA:
undetectable		 1fxvA-2n3eA:
22.17
1fxvB-2n3eA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		5 / 12 ALA A  91
ALA A  95
PHE A  70
GLN A  76
ILE A  43
 None
 1.21A 2jjpA-2n3eA:
undetectable		 2jjpA-2n3eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		4 / 5 PHE A  70
ALA A  75
THR A  88
LEU A  96
 None
 1.19A 3t3zC-2n3eA:
undetectable		 3t3zC-2n3eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		5 / 12 ILE A 119
ILE A 115
ALA A  26
ILE A  23
PHE A 111
 None
 1.08A 3uvvA-2n3eA:
undetectable		 3uvvA-2n3eA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		5 / 12 ASP A  84
LEU A  96
ASP A  94
ALA A  78
GLY A 120
 None
 1.10A 5syeB-2n3eA:
undetectable		 5syeB-2n3eA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2n3e MAJOR AMPULLATE
SPIDROIN 1
(Latrodectus
hesperus) 		4 / 8 ILE A  43
THR A  88
VAL A  87
SER A  27
 None
 0.98A 6fbvC-2n3eA:
undetectable		 6fbvC-2n3eA:
8.08