SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 538
GLY A 540
ILE A 546
PHE A 534
LEU A 506
 None
 1.41A 4kosA-2n3wA:
undetectable		 4kosA-2n3wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 538
GLY A 540
ILE A 546
PHE A 534
LEU A 506
 None
 1.45A 4kotA-2n3wA:
undetectable		 4kotA-2n3wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 498
ALA A 496
ILE A 495
ALA A 526
LEU A 491
 None
 1.02A 4v1fA-2n3wA:
undetectable
4v1fB-2n3wA:
undetectable		 4v1fA-2n3wA:
22.14
4v1fB-2n3wA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 550
ILE A 588
LEU A 585
ALA A 607
 None
 0.82A 6b5vA-2n3wA:
undetectable
6b5vC-2n3wA:
undetectable		 6b5vA-2n3wA:
19.70
6b5vC-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 607
PHE A 550
ILE A 588
LEU A 585
 None
 0.84A 6b5vA-2n3wA:
undetectable
6b5vB-2n3wA:
undetectable		 6b5vA-2n3wA:
19.70
6b5vB-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 550
ILE A 588
LEU A 585
ALA A 607
 None
 0.82A 6b5vC-2n3wA:
undetectable
6b5vD-2n3wA:
undetectable		 6b5vC-2n3wA:
19.70
6b5vD-2n3wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2n3w 26S PROTEASOME
REGULATORY SUBUNIT
RPN1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 607
PHE A 550
ILE A 588
LEU A 585
 None
 0.81A 6b5vB-2n3wA:
undetectable
6b5vD-2n3wA:
undetectable		 6b5vB-2n3wA:
19.70
6b5vD-2n3wA:
19.70