SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZSE_A_PAUA600_0 (PANTOTHENATE KINASE)	2n53	MAJOR PRION PROTEIN (Ovis aries)	4 / 7	TYR A 153 ARG A 154 ILE A 142 ASN A 162	None	1.24A	2zseA-2n53A: undetectable	2zseA-2n53A: 16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	2n53	MAJOR PRION PROTEIN (Ovis aries)	5 / 8	LEU A 133 ILE A 185 GLN A 189 VAL A 192 THR A 193	None	0.64A	4ma7A-2n53A: 7.3	4ma7A-2n53A: 89.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	2n53	MAJOR PRION PROTEIN (Ovis aries)	5 / 8	LEU A 133 TYR A 131 ILE A 185 VAL A 192 THR A 193	None	1.50A	4ma7A-2n53A: 7.3	4ma7A-2n53A: 89.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H3D_A_DHIA601_0 (DUF2338 DOMAIN-CONTAINING PROTEIN)	2n53	MAJOR PRION PROTEIN (Ovis aries)	4 / 5	TYR A 148 ASN A 156 TYR A 153 PHE A 144	None	1.00A	6h3dA-2n53A: undetectable	6h3dA-2n53A: 14.78