SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA153_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 ILE A 100
GLU A 127
ALA A 128
VAL A 136
MET A 144
 None
 1.18A 1a29A-2n6aA:
11.8		 1a29A-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 9 ILE A 100
GLU A 127
ALA A 128
VAL A 136
MET A 144
 None
 1.28A 1ctrA-2n6aA:
12.9		 1ctrA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 9 ILE A 100
LEU A 105
MET A 124
ALA A 128
MET A 144
 None
 1.28A 1ctrA-2n6aA:
12.9		 1ctrA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 9 ILE A 100
MET A 124
ALA A 128
VAL A 136
MET A 144
 None
 1.19A 1ctrA-2n6aA:
12.9		 1ctrA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		6 / 11 PHE A  19
ILE A  27
LEU A  32
LEU A  39
VAL A  55
MET A  71
 None
 1.09A 1dtlA-2n6aA:
12.5		 1dtlA-2n6aA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		6 / 11 PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
MET A  51
 None
 1.11A 1dtlA-2n6aA:
12.5		 1dtlA-2n6aA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		6 / 11 PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
VAL A  55
 None
 1.07A 1dtlA-2n6aA:
12.5		 1dtlA-2n6aA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		6 / 11 PHE A  92
ILE A 100
LEU A 105
MET A 109
LEU A 112
MET A 124
 None
 0.79A 1dtlA-2n6aA:
12.5		 1dtlA-2n6aA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 ILE A  27
ILE A  52
VAL A  55
ILE A  63
MET A  71
 None
 1.05A 1linA-2n6aA:
13.3		 1linA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 ILE A  52
GLU A  54
VAL A  55
ILE A  63
MET A  71
 None
 1.12A 1linA-2n6aA:
13.3		 1linA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 ILE A 100
LEU A 105
MET A 124
ILE A 125
MET A 144
 None
 1.23A 1linA-2n6aA:
13.3		 1linA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		8 / 12 PHE A  92
ILE A 100
LEU A 105
MET A 109
MET A 124
ILE A 125
VAL A 136
MET A 144
 None
 1.16A 1lxfC-2n6aA:
8.7		 1lxfC-2n6aA:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		4 / 6 PHE A  19
VAL A  35
LEU A  39
MET A  51
 None
 1.05A 1wrlB-2n6aA:
9.7		 1wrlB-2n6aA:
57.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 ILE A 100
LEU A 105
MET A 109
ALA A 128
VAL A 136
 None
 0.82A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		6 / 8 PHE A  92
ILE A 100
LEU A 105
ALA A 128
VAL A 136
MET A 144
 None
 0.91A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 8 PHE A  92
ILE A 100
LEU A 105
MET A 124
MET A 144
 None
 1.01A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 7 LEU A 105
MET A 109
MET A 124
ALA A 128
MET A 144
 None
 1.28A 4rjdB-2n6aA:
10.6		 4rjdB-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 7 PHE A  92
LEU A 105
MET A 124
ALA A 128
MET A 144
 None
 1.03A 4rjdB-2n6aA:
10.6		 4rjdB-2n6aA:
98.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 10 ALA A 168
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 0.97A 5v02B-2n6aA:
undetectable
5v02R-2n6aA:
7.3		 5v02B-2n6aA:
18.82
5v02R-2n6aA:
83.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens) 		5 / 10 LEU A  32
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 1.12A 5v02B-2n6aA:
undetectable
5v02R-2n6aA:
7.3		 5v02B-2n6aA:
18.82
5v02R-2n6aA:
83.24