SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		3 / 3 TRP A 110
VAL A  99
PRO A 100
 None
 0.87A 1rg1A-2n6jA:
undetectable		 1rg1A-2n6jA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		3 / 3 TRP A 110
VAL A  99
PRO A 100
 None
 0.86A 1rh0A-2n6jA:
undetectable		 1rh0A-2n6jA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		6 / 12 SER A 157
LEU A 204
LEU A 173
ALA A 136
ILE A 137
ALA A 188
 None
 1.18A 2bxcA-2n6jA:
undetectable		 2bxcA-2n6jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 7 SER A 157
ASP A 149
SER A 190
LEU A 218
 None
 0.95A 2cdqB-2n6jA:
undetectable		 2cdqB-2n6jA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 8 HIS A 150
ASP A 155
SER A 157
ASP A 149
 None
 0.98A 2xadA-2n6jA:
undetectable		 2xadA-2n6jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 8 HIS A 150
ASP A 155
SER A 157
ASP A 149
 None
 0.94A 2xadB-2n6jA:
undetectable		 2xadB-2n6jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 8 HIS A 150
ASP A 155
SER A 157
ASP A 149
 None
 0.99A 2xadD-2n6jA:
undetectable		 2xadD-2n6jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		5 / 12 ASP A 111
VAL A 113
TYR A  94
SER A 119
LEU A 116
 None
 1.30A 4a84A-2n6jA:
undetectable		 4a84A-2n6jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 8 LYS A  80
LEU A  82
THR A 120
ALA A 122
 None
 0.80A 4iizB-2n6jA:
undetectable		 4iizB-2n6jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		5 / 12 MET A  57
ILE A  79
VAL A 121
LEU A 123
ALA A 145
 None
 1.05A 4m11B-2n6jA:
undetectable		 4m11B-2n6jA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		5 / 9 VAL A 152
LEU A  61
THR A  37
LEU A  38
ILE A  41
 None
 1.36A 4ubsA-2n6jA:
undetectable		 4ubsA-2n6jA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		3 / 3 VAL A 152
TYR A  68
ALA A  71
 None
 0.47A 4ybnA-2n6jA:
undetectable		 4ybnA-2n6jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		4 / 5 ALA A 192
GLU A 189
ASN A 175
GLU A 185
 None
None
None
ZN  A 301 (-1.5A)
 1.21A 5dwkC-2n6jA:
undetectable		 5dwkC-2n6jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2n6j ZINC METALLOPROTEASE
ZMP1
(Clostridioides
difficile) 		3 / 3 LEU A 215
SER A 213
PHE A 214
 None
 0.65A 6fgcA-2n6jA:
undetectable		 6fgcA-2n6jA:
19.66