SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_A_ACTA1117_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	3 / 3	ASP A 102 ARG A 101 ARG A 99	None	1.05A	2j9dA-2n7aA: undetectable 2j9dC-2n7aA: undetectable	2j9dA-2n7aA: 21.13 2j9dC-2n7aA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_A_SAMA601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	5 / 12	GLU A 75 SER A 105 ILE A 95 VAL A 21 VAL A 27	None	1.07A	5dpdA-2n7aA: undetectable	5dpdA-2n7aA: 13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_A_SAMA601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	5 / 12	SER A 105 ILE A 95 VAL A 134 VAL A 21 VAL A 27	None	1.10A	5dpdA-2n7aA: undetectable	5dpdA-2n7aA: 13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_B_SAMB601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	5 / 12	SER A 105 ILE A 95 VAL A 134 VAL A 21 VAL A 27	None	1.15A	5dpdB-2n7aA: undetectable	5dpdB-2n7aA: 13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OS8_A_ACTA402_0 (CASEIN KINASE II SUBUNIT ALPHA)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	4 / 5	LYS A 116 ARG A 109 ARG A 70 ASN A 67	None	1.39A	5os8A-2n7aA: 0.0	5os8A-2n7aA: 16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B8K_A_W9TA300_0 (GALECTIN-3)	2n7a	SIALIC ACID-BINDING IG-LIKE LECTIN 8 (Homo sapiens)	4 / 7	HIS A 47 ASN A 67 GLU A 111 ARG A 109	None	1.24A	6b8kA-2n7aA: undetectable	6b8kA-2n7aA: 19.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J9D_A_ACTA1117_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",3,"ASP A 102;ARG A 101;ARG A  99","None","1.05A","2j9dA-2n7aA:undetectable;2j9dC-2n7aA:undetectable","2j9dA-2n7aA:21.13;2j9dC-2n7aA:21.13"],["5DPD_A_SAMA601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",5,"GLU A  75;SER A 105;ILE A  95;VAL A  21;VAL A  27","None","1.07A","5dpdA-2n7aA:undetectable","5dpdA-2n7aA:13.10"],["5DPD_A_SAMA601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",5,"SER A 105;ILE A  95;VAL A 134;VAL A  21;VAL A  27","None","1.10A","5dpdA-2n7aA:undetectable","5dpdA-2n7aA:13.10"],["5DPD_B_SAMB601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",5,"SER A 105;ILE A  95;VAL A 134;VAL A  21;VAL A  27","None","1.15A","5dpdB-2n7aA:undetectable","5dpdB-2n7aA:13.10"],["5OS8_A_ACTA402_0","CASEIN KINASE II SUBUNIT ALPHA","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",4,"LYS A 116;ARG A 109;ARG A  70;ASN A  67","None","1.39A","5os8A-2n7aA:0.0","5os8A-2n7aA:16.46"],["6B8K_A_W9TA300_0","GALECTIN-3","2n7a","SIALIC ACID-BINDING IG-LIKE LECTIN 8","Homo sapiens",4,"HIS A  47;ASN A  67;GLU A 111;ARG A 109","None","1.24A","6b8kA-2n7aA:undetectable","6b8kA-2n7aA:19.26"]]