SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 2n8a POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 5 ALA A  19
ALA A  14
LYS A  15
GLU A  12
 None
 1.02A 1e7cA-2n8aA:
undetectable		 1e7cA-2n8aA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 2n8a POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 7 SER A   4
ARG A  10
TYR A  13
LEU A  33
 None
 0.99A 1ibgL-2n8aA:
undetectable		 1ibgL-2n8aA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2n8a POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 5 THR A 124
ILE A 132
LYS A 131
GLU A 133
 None
 1.26A 4ac9C-2n8aA:
undetectable		 4ac9C-2n8aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2n8a POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 11 SER A 177
LEU A 195
PHE A 184
ALA A 115
THR A 109
 None
 1.03A 4uuuB-2n8aA:
undetectable		 4uuuB-2n8aA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2n8a POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 5 HIS A  53
ILE A  28
SER A  25
ALA A  19
 ZN  A1000 (-3.1A)
None
None
None
 1.28A 5msdA-2n8aA:
undetectable		 5msdA-2n8aA:
10.75