SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2n8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 7 PHE A 771
SER A 754
PHE A 792
ALA A 773
 None
 1.22A 1fxvA-2n8yA:
undetectable
1fxvB-2n8yA:
undetectable		 1fxvA-2n8yA:
21.13
1fxvB-2n8yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 5 MET A 864
ALA A 862
TYR A 859
ILE A 861
 None
 1.12A 1upfA-2n8yA:
undetectable		 1upfA-2n8yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 5 MET A 864
ALA A 862
TYR A 859
ILE A 861
 None
 1.11A 1upfC-2n8yA:
undetectable		 1upfC-2n8yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 4 MET A 864
ALA A 862
TYR A 859
ILE A 861
 None
 1.09A 1upfD-2n8yA:
undetectable		 1upfD-2n8yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 8 LEU A 877
THR A 844
VAL A 873
SER A 872
 None
 1.12A 4qknA-2n8yA:
undetectable		 4qknA-2n8yA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2n8y ALPHA-ACTININ-1
(Homo
sapiens) 		4 / 5 SER A 872
VAL A 873
GLY A 875
ALA A 876
 None
 0.87A 5k50A-2n8yA:
undetectable		 5k50A-2n8yA:
19.54