SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2naa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.69A 2iwkA-2naaA:
undetectable		 2iwkA-2naaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.70A 2iwkB-2naaA:
undetectable		 2iwkB-2naaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		5 / 10 ASP A  53
PHE A  70
LEU A  79
ALA A  59
PHE A  62
 None
 1.39A 2wt9A-2naaA:
undetectable		 2wt9A-2naaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.65A 3dtuB-2naaA:
undetectable		 3dtuB-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A  26
CYH A  47
HIS A  50
 ZN  A 102 (-2.2A)
ZN  A 102 (-2.3A)
ZN  A 102 (-2.8A)
 0.86A 3dtuB-2naaA:
undetectable		 3dtuB-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A   9
CYH A  34
HIS A  31
 ZN  A 101 (-2.3A)
ZN  A 101 (-2.3A)
ZN  A 101 (-3.0A)
 0.63A 3dtuD-2naaA:
undetectable		 3dtuD-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		3 / 3 CYH A  26
CYH A  47
HIS A  50
 ZN  A 102 (-2.2A)
ZN  A 102 (-2.3A)
ZN  A 102 (-2.8A)
 0.85A 3dtuD-2naaA:
undetectable		 3dtuD-2naaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2naa HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Mus
musculus) 		4 / 6 VAL A  19
CYH A  47
CYH A  21
HIS A  31
 None
ZN  A 102 (-2.3A)
ZN  A 102 (-2.2A)
ZN  A 101 (-3.0A)
 1.48A 5hrqH-2naaA:
undetectable
5hrqK-2naaA:
undetectable
5hrqL-2naaA:
undetectable		 5hrqH-2naaA:
13.83
5hrqK-2naaA:
25.00
5hrqL-2naaA:
13.83