SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 11 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 154
 None
 1.24A 1akdA-2nadA:
undetectable		 1akdA-2nadA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 9 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 154
 None
 1.11A 1dz8A-2nadA:
undetectable		 1dz8A-2nadA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 9 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 154
 None
 1.10A 1dz9B-2nadA:
undetectable		 1dz9B-2nadA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 PRO A 320
ASP A 289
ASN A 266
ASP A 267
 None
 1.32A 1hpkA-2nadA:
undetectable		 1hpkA-2nadA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 8 ALA A 140
GLY A 121
ILE A 122
PRO A  37
ILE A 351
 None
AZI  A 395 (-3.6A)
NAD  A 394 ( 3.5A)
None
None
 1.16A 1hshD-2nadA:
undetectable		 1hshD-2nadA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 8 GLN A  34
HIS A 379
SER A 380
TYR A 381
 None
NAD  A 394 ( 4.9A)
NAD  A 394 (-2.7A)
None
 1.10A 1nx9C-2nadA:
undetectable		 1nx9C-2nadA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 10 ASP A 308
SER A 334
THR A 143
TYR A 144
SER A 147
 NAD  A 394 (-2.9A)
NAD  A 394 (-2.9A)
None
None
NAD  A 394 (-2.8A)
 1.49A 1rqpA-2nadA:
2.2		 1rqpA-2nadA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 7 LEU A 217
VAL A 194
GLY A 195
VAL A 154
 None
 0.94A 1t88A-2nadA:
undetectable		 1t88A-2nadA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		3 / 3 SER A 334
GLY A 335
ARG A 284
 NAD  A 394 (-2.9A)
NAD  A 394 (-3.4A)
AZI  A 395 ( 3.0A)
 0.41A 1t9wA-2nadA:
undetectable		 1t9wA-2nadA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
AZI  A 395 (-3.6A)
NAD  A 394 (-3.4A)
None
None
 1.23A 2akeA-2nadA:
2.4		 2akeA-2nadA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
AZI  A 395 (-3.6A)
NAD  A 394 (-3.4A)
None
None
 1.24A 2azxA-2nadA:
undetectable		 2azxA-2nadA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 THR A 119
GLY A 121
GLY A 335
ILE A  94
GLN A  96
 None
AZI  A 395 (-3.6A)
NAD  A 394 (-3.4A)
None
None
 1.26A 2azxB-2nadA:
undetectable		 2azxB-2nadA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 10 PHE A  98
GLY A 347
THR A 348
ALA A 345
ALA A 346
 AZI  A 395 ( 4.4A)
None
None
None
None
 0.85A 2ej3B-2nadA:
undetectable		 2ej3B-2nadA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 ILE A 158
LEU A 210
PHE A 213
MET A 192
 None
 0.64A 3adsA-2nadA:
undetectable		 3adsA-2nadA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 5 SER A 149
ARG A 362
GLY A 347
GLU A 350
 None
 1.21A 3k9fA-2nadA:
undetectable
3k9fB-2nadA:
undetectable
3k9fC-2nadA:
2.2		 3k9fA-2nadA:
19.84
3k9fB-2nadA:
19.84
3k9fC-2nadA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 ARG A 359
GLY A 358
GLU A 353
GLU A 357
 None
 1.01A 3k9fA-2nadA:
undetectable
3k9fB-2nadA:
undetectable
3k9fD-2nadA:
2.3		 3k9fA-2nadA:
19.84
3k9fB-2nadA:
19.84
3k9fD-2nadA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 7 GLU A 152
VAL A 155
ALA A 205
ARG A 209
 None
 0.99A 3kp6B-2nadA:
undetectable		 3kp6B-2nadA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 8 GLY A  51
GLN A 341
GLN A  96
THR A 336
 None
 0.94A 3rglA-2nadA:
undetectable		 3rglA-2nadA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 7 GLY A 347
THR A 348
ILE A 351
THR A 376
 None
 0.83A 4acaC-2nadA:
3.3		 4acaC-2nadA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 ARG A 349
ILE A  94
VAL A   3
LEU A  70
 None
 0.88A 4em2A-2nadA:
undetectable		 4em2A-2nadA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 ALA A 111
LEU A 103
SER A  95
ILE A  94
LEU A 352
 None
 1.10A 4ky8B-2nadA:
undetectable		 4ky8B-2nadA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 8 LEU A 233
VAL A 229
ALA A 205
HIS A 379
 None
None
None
NAD  A 394 ( 4.9A)
 0.85A 4qrcA-2nadA:
undetectable		 4qrcA-2nadA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 11 LEU A 373
ASP A 125
VAL A 139
THR A 119
ILE A 122
 None
None
None
None
NAD  A 394 ( 3.5A)
 1.32A 4uuuB-2nadA:
undetectable		 4uuuB-2nadA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 ALA A 120
LEU A  59
LEU A  57
LEU A  50
LEU A 118
 None
 1.20A 4zn7A-2nadA:
undetectable		 4zn7A-2nadA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		5 / 12 LEU A 159
GLY A 195
LEU A 189
ASN A 254
GLY A 203
 None
 0.99A 5kb5A-2nadA:
undetectable		 5kb5A-2nadA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		3 / 3 GLU A 364
ARG A 362
TYR A 365
 None
 0.64A 5trqB-2nadA:
undetectable		 5trqB-2nadA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		3 / 3 GLY A 377
THR A 282
PRO A 256
 None
NAD  A 394 (-4.8A)
NAD  A 394 (-3.7A)
 0.63A 5v5zA-2nadA:
undetectable		 5v5zA-2nadA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 GLY A  55
GLN A  48
TYR A  19
TYR A  15
 None
 1.14A 6ag0A-2nadA:
undetectable		 6ag0A-2nadA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 6 GLY A  55
GLN A  48
TYR A  19
TYR A  15
 None
 1.10A 6ag0C-2nadA:
undetectable		 6ag0C-2nadA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE
(Pseudomonas
sp.
101) 		4 / 5 THR A 220
THR A 261
HIS A 258
GLY A 200
 None
NAD  A 394 (-4.4A)
NAD  A 394 (-4.4A)
NAD  A 394 (-3.4A)
 1.21A 6gbnC-2nadA:
5.6		 6gbnC-2nadA:
19.74