SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2naf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A   6
GLY A  77
ALA A  80
LYS A  81
 None
 0.83A 2xfsA-2nafA:
undetectable		 2xfsA-2nafA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A   6
GLY A  77
ALA A  80
LYS A  81
 None
 0.91A 2xh9A-2nafA:
undetectable		 2xh9A-2nafA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 145
HIS A  22
ASP A  95
HIS A 115
 None
 1.15A 3c0zC-2nafA:
3.0		 3c0zC-2nafA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  21
PHE A 149
PRO A 146
 None
 0.81A 3zoaB-2nafA:
undetectable		 3zoaB-2nafA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A  55
ALA A   2
GLU A   3
GLN A  88
SER A  59
 None
 1.41A 4omwD-2nafA:
0.0		 4omwD-2nafA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ASP A 171
LEU A 175
LEU A 176
LEU A 106
ALA A 184
 None
 1.10A 5dqfA-2nafA:
undetectable		 5dqfA-2nafA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 113
GLU A  96
ILE A  99
VAL A 137
PRO A 140
 None
 1.23A 5hjiA-2nafA:
undetectable		 5hjiA-2nafA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  79
VAL A  92
VAL A   8
LEU A  55
THR A 173
 None
 1.20A 6b52A-2nafA:
2.4		 6b52A-2nafA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  94
GLY A 114
VAL A 137
ILE A  90
GLY A 110
 None
 1.18A 6c2mB-2nafA:
undetectable		 6c2mB-2nafA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  94
GLY A 114
VAL A 137
ILE A  90
GLY A 110
 None
 0.95A 6c2mD-2nafA:
undetectable		 6c2mD-2nafA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2naf PEPTIDYL-TRNA
HYDROLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 HIS A 131
VAL A 188
LEU A 106
ALA A 184
 None
 1.23A 6d8pB-2nafA:
4.1		 6d8pB-2nafA:
14.12