SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2naq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DDR_B_MTXB200_1 (DIHYDROFOLATE REDUCTASE)	2naq	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ILE A 72 ASP A 19 LEU A 20 PHE A 23 LEU A 52	None	1.09A	1ddrB-2naqA: undetectable	1ddrB-2naqA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DYI_B_FOLB161_0 (DIHYDROFOLATE REDUCTASE)	2naq	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ILE A 72 ASP A 19 LEU A 20 PHE A 23 LEU A 52	None	1.07A	1dyiB-2naqA: undetectable	1dyiB-2naqA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QLG_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	2naq	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ILE A 72 ASP A 19 LEU A 20 PHE A 23 LEU A 52	None	1.12A	4qlgB-2naqA: undetectable	4qlgB-2naqA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RGC_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2naq	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ILE A 72 ASP A 19 LEU A 20 PHE A 23 LEU A 52	None	1.11A	4rgcA-2naqA: undetectable	4rgcA-2naqA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X5G_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2naq	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ILE A 72 ASP A 19 LEU A 20 PHE A 23 LEU A 52	None	1.13A	4x5gA-2naqA: undetectable	4x5gA-2naqA: 20.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DDR_B_MTXB200_1","DIHYDROFOLATE REDUCTASE","2naq","NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","Homo sapiens",5,"ILE A  72;ASP A  19;LEU A  20;PHE A  23;LEU A  52","None","1.09A","1ddrB-2naqA:undetectable","1ddrB-2naqA:20.75"],["1DYI_B_FOLB161_0","DIHYDROFOLATE REDUCTASE","2naq","NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","Homo sapiens",5,"ILE A  72;ASP A  19;LEU A  20;PHE A  23;LEU A  52","None","1.07A","1dyiB-2naqA:undetectable","1dyiB-2naqA:21.38"],["4QLG_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","2naq","NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","Homo sapiens",5,"ILE A  72;ASP A  19;LEU A  20;PHE A  23;LEU A  52","None","1.12A","4qlgB-2naqA:undetectable","4qlgB-2naqA:20.75"],["4RGC_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2naq","NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","Homo sapiens",5,"ILE A  72;ASP A  19;LEU A  20;PHE A  23;LEU A  52","None","1.11A","4rgcA-2naqA:undetectable","4rgcA-2naqA:20.75"],["4X5G_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2naq","NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","Homo sapiens",5,"ILE A  72;ASP A  19;LEU A  20;PHE A  23;LEU A  52","None","1.13A","4x5gA-2naqA:undetectable","4x5gA-2naqA:20.75"]]