SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QOM_A_H4BA902_1 (NITRIC OXIDE SYNTHASE)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ARG A 113 ILE A 64 TRP A 42	None	1.12A	1qomA-2nbaA: undetectable	1qomA-2nbaA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NOD_B_H4BB902_1 (NITRIC OXIDE SYNTHASE)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ARG A 113 ILE A 64 TRP A 42	None	1.13A	2nodB-2nbaA: undetectable	2nodB-2nbaA: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7I_B_H4BB2902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ARG A 113 ILE A 64 TRP A 42	None	1.16A	3e7iB-2nbaA: undetectable	3e7iB-2nbaA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP3_B_AICB2002_1 (TRANSCRIPTIONAL REGULATOR TCAR)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ALA A 93 ARG A 86 LYS A 68	None	0.89A	3kp3B-2nbaA: undetectable	3kp3B-2nbaA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NW2_A_H4BA902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ARG A 113 ILE A 64 TRP A 42	None	1.09A	3nw2A-2nbaA: undetectable	3nw2A-2nbaA: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NW2_B_H4BB902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	3 / 3	ARG A 113 ILE A 64 TRP A 42	None	1.06A	3nw2B-2nbaA: undetectable	3nw2B-2nbaA: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	4 / 6	PHE A 112 LEU A 65 ARG A 113 GLY A 63	None	1.01A	5o4yA-2nbaA: undetectable	5o4yA-2nbaA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIG_A_EDTA501_0 (ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A)	2nba	PREPILIN-TYPE CLEAVAGE/METHYLATION N-TERMINAL DOMAIN PROTEIN (Neisseria subflava)	4 / 6	THR A 70 ARG A 86 ILE A 64 GLU A 66	None	1.13A	5uigA-2nbaA: undetectable	5uigA-2nbaA: 13.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QOM_A_H4BA902_1","NITRIC OXIDE SYNTHASE","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ARG A 113;ILE A  64;TRP A  42","None","1.12A","1qomA-2nbaA:undetectable","1qomA-2nbaA:15.22"],["2NOD_B_H4BB902_1","NITRIC OXIDE SYNTHASE","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ARG A 113;ILE A  64;TRP A  42","None","1.13A","2nodB-2nbaA:undetectable","2nodB-2nbaA:15.24"],["3E7I_B_H4BB2902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ARG A 113;ILE A  64;TRP A  42","None","1.16A","3e7iB-2nbaA:undetectable","3e7iB-2nbaA:15.22"],["3KP3_B_AICB2002_1","TRANSCRIPTIONAL REGULATOR TCAR","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ALA A  93;ARG A  86;LYS A  68","None","0.89A","3kp3B-2nbaA:undetectable","3kp3B-2nbaA:21.15"],["3NW2_A_H4BA902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ARG A 113;ILE A  64;TRP A  42","None","1.09A","3nw2A-2nbaA:undetectable","3nw2A-2nbaA:15.24"],["3NW2_B_H4BB902_1","NITRIC OXIDE SYNTHASE, INDUCIBLE","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",3,"ARG A 113;ILE A  64;TRP A  42","None","1.06A","3nw2B-2nbaA:undetectable","3nw2B-2nbaA:15.24"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",4,"PHE A 112;LEU A  65;ARG A 113;GLY A  63","None","1.01A","5o4yA-2nbaA:undetectable","5o4yA-2nbaA:9.68"],["5UIG_A_EDTA501_0","ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A","2nba","PREPILIN-TYPE CLEAVAGE\/METHYLATION N-TERMINAL DOMAIN PROTEIN","Neisseria subflava",4,"THR A  70;ARG A  86;ILE A  64;GLU A  66","None","1.13A","5uigA-2nbaA:undetectable","5uigA-2nbaA:13.46"]]