SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		4 / 7 ASP A  73
ASN A  33
SER A  30
ARG A  76
 None
 1.32A 1rqpB-2nbrA:
undetectable		 1rqpB-2nbrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		4 / 6 GLU A  61
PHE A  11
GLN A  67
PRO A  63
 None
 1.27A 2qqtA-2nbrA:
undetectable		 2qqtA-2nbrA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		4 / 7 ASP A  73
ASN A  33
SER A  30
ARG A  76
 None
 1.31A 2v7uB-2nbrA:
undetectable		 2v7uB-2nbrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		5 / 12 CYH A  78
SER A  77
LEU A  25
THR A  20
THR A  18
 None
 1.21A 3a35A-2nbrA:
undetectable		 3a35A-2nbrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		5 / 12 CYH A  78
SER A  77
LEU A  25
THR A  20
THR A  18
 None
 1.21A 3a3bA-2nbrA:
undetectable		 3a3bA-2nbrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		4 / 6 GLU A  61
PHE A  11
GLN A  67
PRO A  63
 None
 1.32A 3gclA-2nbrA:
undetectable		 3gclA-2nbrA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		4 / 4 GLN A 148
PRO A 147
VAL A 125
GLU A 127
 None
 1.47A 3huoA-2nbrA:
undetectable		 3huoA-2nbrA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		5 / 12 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.17A 6ew0F-2nbrA:
undetectable		 6ew0F-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		5 / 12 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.18A 6ew0G-2nbrA:
undetectable		 6ew0G-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2nbr GAMMA-CRYSTALLIN C
(Homo
sapiens) 		3 / 3 TYR A  62
ASP A  64
GLN A  67
 None
 0.85A 6g1pA-2nbrA:
undetectable		 6g1pA-2nbrA:
17.73