SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 125
LEU A 110
LEU A 139
GLN A 161
ILE A  44
 None
 1.08A 3datA-2nc8A:
undetectable		 3datA-2nc8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 102
ALA A 106
SER A 103
LEU A 110
 None
 1.19A 4ijiF-2nc8A:
undetectable		 4ijiF-2nc8A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		4 / 8 SER A  41
ALA A 142
SER A  35
THR A  33
 None
 1.00A 4ikjA-2nc8A:
undetectable
4ikjB-2nc8A:
undetectable		 4ikjA-2nc8A:
22.04
4ikjB-2nc8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		4 / 7 SER A  41
ALA A 142
SER A  35
THR A  33
 None
 1.01A 4ikkA-2nc8A:
undetectable
4ikkB-2nc8A:
undetectable		 4ikkA-2nc8A:
22.04
4ikkB-2nc8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 164
ALA A 125
ALA A  30
VAL A  28
ILE A  44
 None
 0.83A 4x1yB-2nc8A:
undetectable		 4x1yB-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 164
ALA A 125
LEU A 110
ALA A  30
VAL A  28
 None
 1.04A 4x1yB-2nc8A:
undetectable		 4x1yB-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 164
ALA A 125
ALA A  30
VAL A  28
ILE A  44
 None
 0.99A 4x20B-2nc8A:
undetectable		 4x20B-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  85
ILE A  44
GLY A  82
ALA A 105
ASP A 104
 None
 1.22A 5ajqB-2nc8A:
undetectable		 5ajqB-2nc8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 112
LEU A 110
GLY A 123
GLU A 122
 None
 1.24A 5hhjA-2nc8A:
undetectable		 5hhjA-2nc8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  60
ALA A  71
SER A  88
SER A  41
LEU A  90
 None
 1.20A 5mwyA-2nc8A:
undetectable		 5mwyA-2nc8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 138
VAL A 137
LEU A  98
ALA A 106
GLY A 123
 None
 1.24A 5syeB-2nc8A:
undetectable		 5syeB-2nc8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2nc8 LIPOPROTEIN LPPM
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 125
LEU A 110
PHE A  66
VAL A  70
ALA A  30
 None
 1.17A 6djzC-2nc8A:
undetectable		 6djzC-2nc8A:
23.98