SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 6 TYR R 131
VAL R  64
ILE R  68
LEU R  74
 None
 1.32A 1j96A-2nckR:
undetectable		 1j96A-2nckR:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 7 PHE R 133
GLU R 128
ARG R  38
VAL R  76
 None
 1.49A 1p6iA-2nckR:
undetectable
1p6iB-2nckR:
undetectable		 1p6iA-2nckR:
16.15
1p6iB-2nckR:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 6 MET R  67
VAL R  64
LEU R  63
PHE R  59
 None
 0.90A 1x8vA-2nckR:
undetectable		 1x8vA-2nckR:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 8 LEU R   7
ILE R   9
PHE R  50
ARG R  38
 None
 0.93A 2azxA-2nckR:
undetectable		 2azxA-2nckR:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		3 / 3 LEU R  63
TYR R  51
GLY R  49
 None
 0.60A 2ocuA-2nckR:
undetectable		 2ocuA-2nckR:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		5 / 12 MET R  67
LEU R  63
PHE R  59
ILE R 111
LEU R   7
 None
 1.25A 2po7B-2nckR:
undetectable		 2po7B-2nckR:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 8 MET R  67
LEU R  63
ARG R 104
GLY R 118
 None
 1.08A 2qd5A-2nckR:
undetectable		 2qd5A-2nckR:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 7 PHE R 133
GLU R 128
ARG R  38
VAL R  76
 None
 1.49A 3hsoA-2nckR:
undetectable
3hsoB-2nckR:
undetectable		 3hsoA-2nckR:
16.15
3hsoB-2nckR:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 7 ASN R  81
GLU R  80
GLU R  78
GLU R   4
 None
 1.30A 4mj8C-2nckR:
undetectable		 4mj8C-2nckR:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 7 ASN R  81
GLU R  80
GLU R  78
GLU R   4
 None
 1.35A 4r87I-2nckR:
2.3		 4r87I-2nckR:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		4 / 5 LYS R 126
LEU R 122
ALA R 125
VAL R  76
 None
 1.19A 5cr1A-2nckR:
undetectable		 5cr1A-2nckR:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2nck NUCLEOSIDE
DIPHOSPHATE KINASE
(Myxococcus
xanthus) 		6 / 12 GLY R 101
ALA R 108
PHE R  27
ILE R  23
THR R 115
GLY R  91
 None
 1.43A 5hieB-2nckR:
undetectable		 5hieB-2nckR:
19.27