SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nd1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_D_ACTD37_0 (GCN4 LEUCINE ZIPPER)	2nd1	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	3 / 3	LYS A 24 ARG A 76 VAL A 71	None	1.01A	2r2vC-2nd1A: undetectable 2r2vD-2nd1A: undetectable	2r2vC-2nd1A: 20.25 2r2vD-2nd1A: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O1C_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	2nd1	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	5 / 10	ILE A 37 ILE A 36 ILE A 22 SER A 19 LEU A 64	None	0.98A	3o1cA-2nd1A: undetectable	3o1cA-2nd1A: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI507_0 (RNA POLYMERASE 3D-POL)	2nd1	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	3 / 3	LYS A 60 PRO A 61 SER A 62	None	0.42A	4k50I-2nd1A: undetectable	4k50I-2nd1A: 11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XDT_A_ACTA406_0 (FAD:PROTEIN FMN TRANSFERASE)	2nd1	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	4 / 5	SER A 19 ARG A 16 LEU A 20 ASP A 21	None	1.35A	4xdtA-2nd1A: undetectable	4xdtA-2nd1A: 13.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2R2V_D_ACTD37_0","GCN4 LEUCINE ZIPPER","2nd1","BROMODOMAIN-CONTAINING PROTEIN 4","Homo sapiens",3,"LYS A  24;ARG A  76;VAL A  71","None","1.01A","2r2vC-2nd1A:undetectable;2r2vD-2nd1A:undetectable","2r2vC-2nd1A:20.25;2r2vD-2nd1A:20.25"],["3O1C_A_ADNA127_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1","2nd1","BROMODOMAIN-CONTAINING PROTEIN 4","Homo sapiens",5,"ILE A  37;ILE A  36;ILE A  22;SER A  19;LEU A  64","None","0.98A","3o1cA-2nd1A:undetectable","3o1cA-2nd1A:19.84"],["4K50_I_ACTI507_0","RNA POLYMERASE 3D-POL","2nd1","BROMODOMAIN-CONTAINING PROTEIN 4","Homo sapiens",3,"LYS A  60;PRO A  61;SER A  62","None","0.42A","4k50I-2nd1A:undetectable","4k50I-2nd1A:11.72"],["4XDT_A_ACTA406_0","FAD:PROTEIN FMN TRANSFERASE","2nd1","BROMODOMAIN-CONTAINING PROTEIN 4","Homo sapiens",4,"SER A  19;ARG A  16;LEU A  20;ASP A  21","None","1.35A","4xdtA-2nd1A:undetectable","4xdtA-2nd1A:13.89"]]