SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 7 ARG A 136
ASN A 133
ASP A 140
LYS A 177
 None
 1.35A 1hwiC-2nd4A:
undetectable		 1hwiC-2nd4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 7 ARG A 136
ASN A 133
ASP A 140
LYS A 177
 None
 1.35A 1hwiD-2nd4A:
undetectable		 1hwiD-2nd4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		5 / 10 GLY A 157
ASN A 156
TYR A 159
GLU A 134
ARG A  32
 None
 1.05A 2piwA-2nd4A:
undetectable		 2piwA-2nd4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 8 ARG A 100
ASN A  39
ILE A 104
TRP A  31
 None
 0.95A 4d33A-2nd4A:
undetectable		 4d33A-2nd4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 8 ARG A 100
ASN A  39
ILE A 104
TRP A  31
 None
 1.00A 4d39A-2nd4A:
undetectable		 4d39A-2nd4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 4 VAL A 169
ALA A 181
ILE A 141
THR A 145
 None
 1.18A 5e4dB-2nd4A:
undetectable		 5e4dB-2nd4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2nd4 AMYLASE-BINDING
PROTEIN ABPA
(Streptococcus
parasanguinis) 		4 / 6 TYR A 122
GLN A 118
GLU A  37
THR A 132
 None
 1.29A 6djzA-2nd4A:
undetectable		 6djzA-2nd4A:
22.22