SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A 111
ILE A 114
LEU A  87
TYR A 143
 None
 1.07A 2ya7A-2nefA:
undetectable		 2ya7A-2nefA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A 111
ILE A 114
LEU A  87
TYR A 143
 None
 1.03A 2ya7B-2nefA:
undetectable		 2ya7B-2nefA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A 111
ILE A 114
LEU A  87
TYR A 143
 None
 1.04A 2ya7D-2nefA:
undetectable		 2ya7D-2nefA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		3 / 3 HIS A 193
ARG A 196
GLU A 197
 None
 1.16A 3qf1A-2nefA:
undetectable		 3qf1A-2nefA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		3 / 3 ASN A 205
ALA A 206
LYS A 204
 None
 0.70A 3runA-2nefA:
undetectable		 3runA-2nefA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		3 / 3 TYR A 127
ASP A 111
ASP A 123
 None
 0.73A 4a6eA-2nefA:
undetectable		 4a6eA-2nefA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 5 GLN A 118
THR A 117
LEU A  97
LEU A  91
 None
 0.94A 4lvcB-2nefA:
undetectable		 4lvcB-2nefA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 4 GLN A 118
THR A 117
LEU A  97
LEU A  91
 None
 0.93A 5m5kB-2nefA:
undetectable		 5m5kB-2nefA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 6 PHE A 185
LEU A  97
ARG A 184
GLY A  99
 None
 0.87A 5o4yA-2nefA:
undetectable		 5o4yA-2nefA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 5 LEU A  91
LEU A  97
GLN A 118
TYR A 120
 None
 1.41A 5uc3A-2nefA:
undetectable		 5uc3A-2nefA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2nef NEGATIVE FACTOR
(F-PROTEIN)
(Human
immunodeficiency
virus
1) 		4 / 8 LEU A 189
TYR A  81
VAL A  85
HIS A  89
 None
 0.99A 5v0vA-2nefA:
undetectable		 5v0vA-2nefA:
12.01