SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ng1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 9 LEU A   9
LEU A  82
ALA A  59
LEU A  31
PHE A  51
 None
 1.23A 1tbfA-2ng1A:
undetectable		 1tbfA-2ng1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A  36
VAL A  43
THR A  48
 None
 0.88A 2nnkA-2ng1A:
undetectable		 2nnkA-2ng1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 6 ILE A  13
ARG A  15
LEU A  16
LEU A   9
 None
 0.91A 2rlfA-2ng1A:
undetectable
2rlfD-2ng1A:
undetectable		 2rlfA-2ng1A:
10.20
2rlfD-2ng1A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 8 LEU A   9
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.24A 2vcvF-2ng1A:
undetectable		 2vcvF-2ng1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 6 PHE A  51
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.33A 2vcvK-2ng1A:
undetectable		 2vcvK-2ng1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 THR A  48
LEU A  31
ILE A  13
ILE A  74
LEU A   5
 None
 1.25A 3gwxA-2ng1A:
undetectable		 3gwxA-2ng1A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		6 / 12 ILE A 184
PRO A 129
ALA A 119
ALA A 133
VAL A 132
PRO A 155
 None
 1.36A 3jb2A-2ng1A:
undetectable		 3jb2A-2ng1A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A  36
VAL A  43
THR A  48
 None
 0.87A 3k4vA-2ng1A:
undetectable		 3k4vA-2ng1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 5 ARG A  36
LEU A   5
ARG A  15
ILE A  13
 None
 1.30A 3ln1D-2ng1A:
undetectable		 3ln1D-2ng1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 7 LEU A 198
ASP A 135
ARG A 138
ALA A 189
 EDO  A 971 ( 4.1A)
None
None
None
 1.15A 3mbgA-2ng1A:
4.9
3mbgB-2ng1A:
4.9		 3mbgA-2ng1A:
19.32
3mbgB-2ng1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A  36
VAL A  43
THR A  48
 None
 0.87A 3nduD-2ng1A:
undetectable		 3nduD-2ng1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A  36
VAL A  43
THR A  48
 None
 0.81A 3pwrA-2ng1A:
undetectable		 3pwrA-2ng1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 6 PHE A 282
LEU A 257
THR A 263
LEU A 244
 DIO  A 800 ( 4.8A)
None
None
None
 0.99A 3t3zB-2ng1A:
undetectable		 3t3zB-2ng1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A  36
VAL A  43
THR A  48
 None
 0.86A 3tl9A-2ng1A:
undetectable		 3tl9A-2ng1A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 8 ASP A 187
VAL A 172
PHE A 102
LEU A 205
 None
 1.02A 4f8hA-2ng1A:
2.0
4f8hB-2ng1A:
2.0		 4f8hA-2ng1A:
21.68
4f8hB-2ng1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 11 LEU A 257
LEU A   5
LEU A  86
VAL A  78
LEU A 292
 None
 1.11A 4p65C-2ng1A:
undetectable
4p65D-2ng1A:
undetectable
4p65J-2ng1A:
undetectable
4p65L-2ng1A:
undetectable		 4p65C-2ng1A:
5.15
4p65D-2ng1A:
7.64
4p65J-2ng1A:
7.64
4p65L-2ng1A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 11 LEU A  86
VAL A  78
LEU A 292
LEU A 257
LEU A   5
 None
 1.09A 4p65B-2ng1A:
undetectable
4p65D-2ng1A:
undetectable
4p65G-2ng1A:
undetectable
4p65H-2ng1A:
undetectable		 4p65B-2ng1A:
7.64
4p65D-2ng1A:
7.64
4p65G-2ng1A:
5.15
4p65H-2ng1A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		6 / 9 LEU A  86
ALA A 255
LEU A 244
ALA A 220
LEU A 247
LEU A 287
 None
None
None
None
None
DIO  A 800 ( 4.0A)
 1.24A 4z91F-2ng1A:
undetectable
4z91G-2ng1A:
2.5
4z91H-2ng1A:
undetectable
4z91I-2ng1A:
2.1
4z91J-2ng1A:
2.3		 4z91F-2ng1A:
20.23
4z91G-2ng1A:
20.23
4z91H-2ng1A:
20.23
4z91I-2ng1A:
20.23
4z91J-2ng1A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		6 / 9 LEU A 244
ALA A 220
LEU A 247
LEU A 287
LEU A  86
ALA A 255
 None
None
None
DIO  A 800 ( 4.0A)
None
None
 1.20A 4z91F-2ng1A:
undetectable
4z91G-2ng1A:
2.5
4z91H-2ng1A:
undetectable
4z91I-2ng1A:
2.1
4z91J-2ng1A:
2.3		 4z91F-2ng1A:
20.23
4z91G-2ng1A:
20.23
4z91H-2ng1A:
20.23
4z91I-2ng1A:
20.23
4z91J-2ng1A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 8 LEU A 287
PHE A   2
GLY A 254
LEU A 244
 DIO  A 800 ( 4.0A)
None
None
None
 0.84A 5eseA-2ng1A:
undetectable		 5eseA-2ng1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.30A 5eypB-2ng1A:
undetectable		 5eypB-2ng1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 THR A 188
THR A 112
THR A 113
ALA A 116
GLY A 105
 None
GDP  A 900 (-4.2A)
GDP  A 900 (-3.6A)
EDO  A 973 ( 4.6A)
EDO  A 971 (-4.8A)
 1.19A 5lf7H-2ng1A:
2.8
5lf7N-2ng1A:
undetectable		 5lf7H-2ng1A:
19.47
5lf7N-2ng1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.28A 5nm5B-2ng1A:
3.8		 5nm5B-2ng1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		4 / 7 LEU A 131
LEU A 103
THR A 112
ALA A 115
 None
None
GDP  A 900 (-4.2A)
None
 0.71A 5o96C-2ng1A:
2.3		 5o96C-2ng1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 10 LEU A 131
LEU A 185
LEU A 103
THR A 112
ALA A 115
 None
None
None
GDP  A 900 (-4.2A)
None
 0.89A 5o96G-2ng1A:
undetectable
5o96H-2ng1A:
undetectable		 5o96G-2ng1A:
22.88
5o96H-2ng1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		3 / 3 ARG A 181
ARG A 127
ARG A  98
 None
 0.84A 5vcgA-2ng1A:
0.7		 5vcgA-2ng1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.29A 5xiwD-2ng1A:
3.4		 5xiwD-2ng1A:
12.54