SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ngr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		4 / 6 PHE B 265
LEU B 348
VAL B 285
GLN B 264
 None
 1.11A 1e7aB-2ngrB:
undetectable		 1e7aB-2ngrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		5 / 12 ALA B 305
LEU B 415
ALA B 416
PHE B 419
LEU B 394
 None
 1.02A 4psyA-2ngrB:
undetectable		 4psyA-2ngrB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		5 / 11 LEU B 391
TYR B 388
LEU B 446
LEU B 453
LEU B 380
 None
 0.91A 4wg0C-2ngrB:
undetectable
4wg0D-2ngrB:
undetectable
4wg0E-2ngrB:
undetectable		 4wg0C-2ngrB:
5.97
4wg0D-2ngrB:
5.97
4wg0E-2ngrB:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		5 / 11 LEU B 391
TYR B 388
LEU B 446
LEU B 453
LEU B 380
 None
 0.90A 4wg0E-2ngrB:
undetectable
4wg0F-2ngrB:
undetectable
4wg0G-2ngrB:
undetectable		 4wg0E-2ngrB:
5.97
4wg0F-2ngrB:
5.97
4wg0G-2ngrB:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		4 / 7 LEU B 446
PHE B 442
ILE B 436
ASN B 422
 None
 1.01A 5n5dA-2ngrB:
undetectable		 5n5dA-2ngrB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ngr PROTEIN (GTPASE
ACTIVATING PROTEIN
(RHG))
(Homo
sapiens) 		4 / 7 LEU B 391
PHE B 454
LEU B 446
PHE B 442
 None
 1.04A 5x1fP-2ngrB:
undetectable
5x1fW-2ngrB:
undetectable		 5x1fP-2ngrB:
21.65
5x1fW-2ngrB:
14.29