SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 252
ASP A 250
VAL A 287
PRO A 292
ILE A 260
 None
 1.11A 1hpvB-2nliA:
undetectable		 1hpvB-2nliA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 5 ALA A 148
TYR A 146
ALA A 217
GLN A 269
 None
 1.15A 1xl6A-2nliA:
undetectable
1xl6B-2nliA:
undetectable		 1xl6A-2nliA:
21.15
1xl6B-2nliA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 8 SER A 276
SER A 263
SER A 297
ASN A  54
 None
FMN  A1375 (-3.3A)
FMN  A1375 (-4.0A)
None
 1.09A 2cmlD-2nliA:
undetectable		 2cmlD-2nliA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ILE A  14
GLY A 330
GLY A 329
ALA A 100
ALA A 111
 None
 0.95A 3jb2A-2nliA:
undetectable		 3jb2A-2nliA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 6 VAL A 112
ILE A  41
ALA A 334
LEU A 338
 None
FMN  A1375 ( 4.3A)
None
None
 0.85A 3kk6B-2nliA:
undetectable		 3kk6B-2nliA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 8 PHE A 193
TYR A   8
ALA A  96
THR A 108
 None
 0.96A 3l4dA-2nliA:
undetectable		 3l4dA-2nliA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 7 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.19A 4fevB-2nliA:
undetectable		 4fevB-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 7 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.23A 4fevD-2nliA:
undetectable		 4fevD-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 7 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.21A 4fewB-2nliA:
undetectable		 4fewB-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 7 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.23A 4gkhG-2nliA:
undetectable		 4gkhG-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 6 ASP A  24
ASP A  55
ASN A  21
GLU A  27
 None
 1.22A 4gkhJ-2nliA:
undetectable		 4gkhJ-2nliA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 7 ASP A 296
SER A 297
HIS A 265
SER A 263
 FMN  A1375 (-2.8A)
FMN  A1375 (-4.0A)
PEO  A1377 ( 4.0A)
FMN  A1375 (-3.3A)
 0.83A 4k7gB-2nliA:
undetectable		 4k7gB-2nliA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		5 / 8 ALA A 252
ASP A 250
VAL A 287
PRO A 292
ILE A 260
 None
 1.21A 4ll3A-2nliA:
undetectable		 4ll3A-2nliA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 252
ASP A 250
VAL A 287
PRO A 292
ILE A 260
 None
 1.20A 4ll3B-2nliA:
undetectable		 4ll3B-2nliA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		3 / 3 ASN A 264
SER A 297
ARG A 320
 None
FMN  A1375 (-4.0A)
FMN  A1375 (-3.9A)
 0.96A 5b2qA-2nliA:
undetectable		 5b2qA-2nliA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 5 VAL A 299
ARG A 300
PRO A 321
GLY A 319
 None
FMN  A1375 (-2.9A)
None
FMN  A1375 (-3.3A)
 1.03A 5x80A-2nliA:
undetectable
5x80B-2nliA:
undetectable		 5x80A-2nliA:
19.55
5x80B-2nliA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2nli LACTATE OXIDASE
(Aerococcus
viridans) 		4 / 5 SER A 223
ARG A 225
ASP A 226
LYS A 219
 None
 1.45A 6dwdA-2nliA:
undetectable		 6dwdA-2nliA:
22.20