SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 7 TYR A 989
THR A1366
ASN A1373
TYR A1215
 None
 1.26A 1afsA-2nlkA:
undetectable		 1afsA-2nlkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 7 TYR A 989
THR A1366
ASN A1373
TYR A1215
 None
 1.26A 1afsB-2nlkA:
undetectable		 1afsB-2nlkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 10 ILE A1222
ALA A1355
ASP A1351
ILE A1403
ILE A1386
 None
 1.15A 1j3jA-2nlkA:
2.4		 1j3jA-2nlkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.27A 1v54A-2nlkA:
0.0
1v54B-2nlkA:
1.2
1v54T-2nlkA:
0.0		 1v54A-2nlkA:
21.20
1v54B-2nlkA:
16.56
1v54T-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.22A 1v55G-2nlkA:
0.0
1v55N-2nlkA:
0.4
1v55O-2nlkA:
0.9		 1v55G-2nlkA:
8.51
1v55N-2nlkA:
21.20
1v55O-2nlkA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 ILE A1222
ALA A1355
ASP A1351
ILE A1403
ILE A1386
 None
 1.18A 2bl9A-2nlkA:
undetectable		 2bl9A-2nlkA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.22A 2eikG-2nlkA:
0.0
2eikN-2nlkA:
0.3
2eikO-2nlkA:
1.1		 2eikG-2nlkA:
8.51
2eikN-2nlkA:
21.20
2eikO-2nlkA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 CYH A1316
GLN A1315
HIS A1350
LEU A1361
TYR A1262
 None
 0.97A 2prgA-2nlkA:
0.0		 2prgA-2nlkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ASN A 878
ASN A 908
ARG A1099
 None
 0.76A 2rlcA-2nlkA:
undetectable		 2rlcA-2nlkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ASN A1179
ASN A1207
ARG A1390
 None
 0.83A 2rlcA-2nlkA:
undetectable		 2rlcA-2nlkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 7 LEU A1089
ASN A1087
LEU A1116
MET A1076
 None
 1.26A 2w8yA-2nlkA:
undetectable		 2w8yA-2nlkA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ASP A1297
PHE A1298
LEU A1300
 None
 0.63A 2zi9A-2nlkA:
undetectable		 2zi9A-2nlkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.31A 2zxwA-2nlkA:
0.3
2zxwB-2nlkA:
1.1
2zxwT-2nlkA:
0.0		 2zxwA-2nlkA:
21.20
2zxwB-2nlkA:
16.56
2zxwT-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ARG A 890
ASP A 934
ASN A 874
 None
 0.86A 2zzmA-2nlkA:
undetectable		 2zzmA-2nlkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.34A 3abmA-2nlkA:
0.3
3abmB-2nlkA:
1.2
3abmT-2nlkA:
0.0		 3abmA-2nlkA:
21.20
3abmB-2nlkA:
16.56
3abmT-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 CYH A1316
HIS A1350
LEU A1285
HIS A1313
TYR A1262
 None
 1.48A 3adsA-2nlkA:
undetectable		 3adsA-2nlkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 CYH A1316
GLN A1315
HIS A1350
LEU A1361
TYR A1262
 None
 1.05A 3adxA-2nlkA:
undetectable		 3adxA-2nlkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 CYH A1316
HIS A1350
LEU A1285
HIS A1313
TYR A1262
 None
 1.47A 3adxA-2nlkA:
undetectable		 3adxA-2nlkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.34A 3ag1A-2nlkA:
0.0
3ag1B-2nlkA:
1.1
3ag1T-2nlkA:
0.0		 3ag1A-2nlkA:
21.20
3ag1B-2nlkA:
16.56
3ag1T-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.21A 3ag3G-2nlkA:
0.0
3ag3N-2nlkA:
0.0
3ag3O-2nlkA:
1.2		 3ag3G-2nlkA:
8.51
3ag3N-2nlkA:
21.20
3ag3O-2nlkA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.28A 3asnA-2nlkA:
0.4
3asnB-2nlkA:
0.9
3asnT-2nlkA:
0.0		 3asnA-2nlkA:
21.20
3asnB-2nlkA:
16.56
3asnT-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 11 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.26A 3asoA-2nlkA:
0.0
3asoB-2nlkA:
1.1
3asoT-2nlkA:
0.0		 3asoA-2nlkA:
21.20
3asoB-2nlkA:
16.56
3asoT-2nlkA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 5 VAL A1056
PHE A 994
ARG A1049
ARG A1099
 None
 1.42A 3bjwE-2nlkA:
undetectable		 3bjwE-2nlkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 6 VAL A1018
VAL A1017
ARG A 993
ARG A1012
 None
 1.15A 3bjwF-2nlkA:
undetectable		 3bjwF-2nlkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 9 ALA A1358
VAL A1393
ILE A1386
ILE A1221
PRO A1186
 None
 1.00A 3el4B-2nlkA:
undetectable		 3el4B-2nlkA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 10 ALA A1358
VAL A1393
ILE A1386
ILE A1221
PRO A1186
 None
 1.13A 3el5A-2nlkA:
undetectable		 3el5A-2nlkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ALA A1355
VAL A1356
GLN A1399
 None
 0.67A 3of4B-2nlkA:
undetectable		 3of4B-2nlkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 10 ILE A1222
ALA A1355
ASP A1351
ILE A1403
ILE A1386
 None
 1.18A 3qgtA-2nlkA:
undetectable		 3qgtA-2nlkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 10 ILE A1222
ALA A1355
ASP A1351
ILE A1403
ILE A1386
 None
 1.16A 3qgtB-2nlkA:
undetectable		 3qgtB-2nlkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 ILE A1222
ALA A1355
ASP A1351
ILE A1403
ILE A1386
 None
 1.18A 3ql3A-2nlkA:
undetectable		 3ql3A-2nlkA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 ALA A1358
VAL A1393
ILE A1386
ILE A1221
PRO A1186
 None
 1.02A 4njuA-2nlkA:
undetectable		 4njuA-2nlkA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 ALA A1358
VAL A1393
ILE A1386
ILE A1221
PRO A1186
 None
 1.03A 4njuC-2nlkA:
undetectable		 4njuC-2nlkA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 6 PHE A1220
PRO A1346
ARG A1216
ILE A1245
 None
 1.34A 5ih0A-2nlkA:
undetectable		 5ih0A-2nlkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 CYH A1316
GLN A1315
HIS A1350
LEU A1361
TYR A1262
 None
 0.97A 5ji0D-2nlkA:
0.0		 5ji0D-2nlkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 TYR A1135
TYR A1400
GLN A1153
 None
 1.01A 5jsdA-2nlkA:
undetectable
5jsdB-2nlkA:
undetectable		 5jsdA-2nlkA:
21.40
5jsdB-2nlkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 TYR A1135
TYR A1400
GLN A1153
 None
 1.02A 5jsdB-2nlkA:
undetectable
5jsdC-2nlkA:
undetectable		 5jsdB-2nlkA:
21.40
5jsdC-2nlkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 8 SER A1075
ALA A 920
ILE A 922
ALA A 923
 None
 0.80A 5te8B-2nlkA:
1.2		 5te8B-2nlkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 ILE A1139
LEU A1156
ILE A1403
LEU A1132
LEU A1408
 None
 1.29A 5tiwA-2nlkA:
undetectable		 5tiwA-2nlkA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 12 PHE A1154
PHE A1402
ILE A1333
ILE A1386
ALA A1383
 None
 1.16A 5vc0A-2nlkA:
undetectable		 5vc0A-2nlkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 ARG A 879
ARG A1066
ARG A 958
 None
 1.02A 5vcgA-2nlkA:
undetectable		 5vcgA-2nlkA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		4 / 6 CYH A1316
HIS A1350
HIS A1313
TYR A1262
 None
 1.50A 5ycnA-2nlkA:
0.0		 5ycnA-2nlkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		3 / 3 TYR A1109
ALA A1115
LEU A1116
 None
 0.51A 6ag0C-2nlkA:
undetectable		 6ag0C-2nlkA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens) 		5 / 10 MET A1029
GLY A1030
TRP A1026
GLN A1104
THR A1069
 None
 1.11A 6nmfG-2nlkA:
0.0
6nmfN-2nlkA:
0.8
6nmfO-2nlkA:
0.0		 6nmfG-2nlkA:
8.51
6nmfN-2nlkA:
21.20
6nmfO-2nlkA:
16.56