SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2nll PROTEIN (THYROID
HORMONE RECEPTOR)
(Homo
sapiens) 		4 / 6 CYH B 303
ASP B 308
VAL B 305
GLY B 322
 ZN  B 450 (-2.2A)
None
ZN  B 450 ( 4.9A)
None
 1.01A 1ekjC-2nllB:
undetectable
1ekjD-2nllB:
undetectable		 1ekjC-2nllB:
17.29
1ekjD-2nllB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2nll PROTEIN (THYROID
HORMONE RECEPTOR)
(Homo
sapiens) 		4 / 6 CYH B 303
ASP B 308
VAL B 305
GLY B 322
 ZN  B 450 (-2.2A)
None
ZN  B 450 ( 4.9A)
None
 0.99A 1ekjC-2nllB:
undetectable
1ekjD-2nllB:
undetectable		 1ekjC-2nllB:
17.29
1ekjD-2nllB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 5 ALA A 136
GLY A 154
CYH A 155
LYS A 156
 None
None
ZN  A 250 (-2.3A)
None
 1.29A 2yldA-2nllA:
undetectable		 2yldA-2nllA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 5 ALA A 136
GLY A 154
CYH A 155
LYS A 156
 None
None
ZN  A 250 (-2.3A)
None
 1.19A 2ylgA-2nllA:
undetectable		 2ylgA-2nllA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 8 TYR A 192
TYR A 169
PHE A 158
ILE A 137
 None
 1.02A 3jz0B-2nllA:
undetectable		 3jz0B-2nllA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 5 ALA A 136
GLY A 154
CYH A 155
LYS A 156
 None
None
ZN  A 250 (-2.3A)
None
 1.31A 3zwiA-2nllA:
undetectable		 3zwiA-2nllA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		3 / 3 TYR A 147
LYS A 160
LYS A 156
 None
 0.53A 5dbyA-2nllA:
undetectable		 5dbyA-2nllA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 5 ALA A 136
GLY A 154
CYH A 155
LYS A 156
 None
None
ZN  A 250 (-2.3A)
None
 1.16A 5jliA-2nllA:
undetectable		 5jliA-2nllA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens) 		4 / 5 ALA A 136
GLY A 154
CYH A 155
LYS A 156
 None
None
ZN  A 250 (-2.3A)
None
 1.20A 5jt4A-2nllA:
undetectable		 5jt4A-2nllA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2nll PROTEIN (THYROID
HORMONE RECEPTOR)
(Homo
sapiens) 		5 / 12 GLY B 322
ASN B 355
THR B 330
TYR B 339
TYR B 315
 None
 1.42A 5yf0A-2nllB:
undetectable		 5yf0A-2nllB:
15.06