SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nlx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 ALA A 374
VAL A 369
TRP A 402
 None
 0.84A 1av2C-2nlxA:
undetectable
1av2D-2nlxA:
undetectable		 1av2C-2nlxA:
10.34
1av2D-2nlxA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 6 VAL A 369
GLY A 370
ALA A 294
LEU A 298
 None
 0.62A 1e7bB-2nlxA:
undetectable		 1e7bB-2nlxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 ALA A 429
ALA A 425
LEU A  31
GLY A  72
LEU A   7
 None
 1.06A 1qabF-2nlxA:
undetectable		 1qabF-2nlxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 12 LEU A  95
ASP A  98
GLY A  99
PRO A  92
ALA A  93
ILE A  94
 None
 1.28A 1rl8B-2nlxA:
undetectable		 1rl8B-2nlxA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 ILE A 208
GLY A 205
ILE A 434
SER A 166
GLU A 163
 None
 1.20A 1sg9A-2nlxA:
undetectable		 1sg9A-2nlxA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 6 ARG A 403
SER A 399
ILE A 314
ALA A 407
 None
 0.97A 1w0gA-2nlxA:
undetectable		 1w0gA-2nlxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 ALA A 374
VAL A 369
TRP A 402
 None
 0.87A 1w5uC-2nlxA:
undetectable
1w5uD-2nlxA:
undetectable		 1w5uC-2nlxA:
10.34
1w5uD-2nlxA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 5 ASP A  98
PRO A  92
ALA A  93
ILE A  94
 None
 0.92A 2aofB-2nlxA:
undetectable		 2aofB-2nlxA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A   8
GLY A 230
ASP A 167
ALA A 236
ALA A 238
 None
 1.01A 2bm9F-2nlxA:
undetectable		 2bm9F-2nlxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 8 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 279
 None
 1.40A 2ha4A-2nlxA:
undetectable		 2ha4A-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 8 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 286
 None
 1.17A 2ha4A-2nlxA:
undetectable		 2ha4A-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 7 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 279
 None
 1.40A 2ha4B-2nlxA:
undetectable		 2ha4B-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 7 GLY A 232
GLY A 231
ALA A 235
ALA A 236
HIS A 286
 None
 1.17A 2ha4B-2nlxA:
undetectable		 2ha4B-2nlxA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 LEU A 132
ILE A 142
SER A 166
PRO A 152
TRP A  48
 None
 1.27A 2po7B-2nlxA:
undetectable		 2po7B-2nlxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 156
MET A 160
MET A 199
 None
 0.98A 2vavF-2nlxA:
undetectable		 2vavF-2nlxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 ALA A 235
PHE A 277
ALA A 172
THR A 174
GLY A  79
 None
 1.25A 2ve3B-2nlxA:
undetectable		 2ve3B-2nlxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 8 ALA A 429
ALA A 425
GLY A  75
ALA A 236
 None
 0.83A 2vh3B-2nlxA:
undetectable		 2vh3B-2nlxA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 11 TYR A 259
LEU A 373
LEU A 406
HIS A 381
PRO A 387
 None
 1.27A 2x7hA-2nlxA:
0.0
2x7hB-2nlxA:
0.0		 2x7hA-2nlxA:
23.21
2x7hB-2nlxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 7 MET A 377
ASP A 378
VAL A 390
TYR A 259
 None
 0.90A 2yfbA-2nlxA:
undetectable		 2yfbA-2nlxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 205
ILE A 208
ASP A 170
LEU A 431
VAL A 239
 None
 0.95A 2yqzB-2nlxA:
undetectable		 2yqzB-2nlxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 6 ILE A 393
ILE A 385
LEU A 449
MET A 243
 None
 1.10A 3adsA-2nlxA:
undetectable		 3adsA-2nlxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 MET A 291
LEU A 292
ALA A 294
LEU A 406
LEU A 251
 None
 1.14A 3erdA-2nlxA:
undetectable		 3erdA-2nlxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 257
GLY A 396
GLY A 394
SER A 399
ALA A 294
 None
 1.07A 3kkzB-2nlxA:
undetectable		 3kkzB-2nlxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 12 LEU A 281
GLY A 237
VAL A 422
GLY A 242
LEU A 449
ILE A 393
 None
 1.38A 3ku1A-2nlxA:
undetectable		 3ku1A-2nlxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 12 LEU A 281
GLY A 237
VAL A 422
GLY A 242
LEU A 449
ILE A 393
 None
 1.38A 3ku1C-2nlxA:
undetectable		 3ku1C-2nlxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A  75
VAL A  12
ALA A 425
ALA A 428
LEU A 151
 None
 1.08A 3mteA-2nlxA:
undetectable		 3mteA-2nlxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 11 LEU A  17
GLY A 427
ALA A 425
ASP A   6
GLY A 420
ILE A  15
 None
 1.41A 3nu3B-2nlxA:
undetectable		 3nu3B-2nlxA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 9 LEU A  17
GLY A 427
ALA A 425
ASP A   6
GLY A 420
ILE A  15
 None
 1.43A 3nu4B-2nlxA:
undetectable		 3nu4B-2nlxA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		6 / 9 LEU A  17
GLY A 427
ALA A 425
ASP A   6
GLY A 420
ILE A  15
 None
 1.43A 3nuoB-2nlxA:
undetectable		 3nuoB-2nlxA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 6 LEU A 475
TYR A 476
ARG A 474
LEU A 330
 None
 1.12A 3rd0A-2nlxA:
undetectable		 3rd0A-2nlxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 6 SER A  34
SER A  41
ASP A  98
ARG A 100
 None
 1.25A 4eysA-2nlxA:
1.1		 4eysA-2nlxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 HIS A  78
LEU A 151
ALA A 235
GLY A  75
GLY A   8
 None
 1.24A 4hfpB-2nlxA:
undetectable		 4hfpB-2nlxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 11 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
 None
 0.90A 4j6cA-2nlxA:
undetectable		 4j6cA-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 10 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
 None
 0.92A 4j6cB-2nlxA:
undetectable		 4j6cB-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 11 ALA A 425
ALA A 428
ALA A 429
VAL A  68
LEU A  65
 None
 0.90A 4jbtB-2nlxA:
undetectable		 4jbtB-2nlxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		4 / 7 ASN A 121
MET A 175
GLU A 109
GLU A 271
 None
 1.36A 4mj8C-2nlxA:
undetectable		 4mj8C-2nlxA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 8 ALA A 428
ALA A  74
ILE A   5
ALA A 165
LEU A 156
 None
 1.42A 4v1fA-2nlxA:
undetectable
4v1fB-2nlxA:
undetectable		 4v1fA-2nlxA:
9.71
4v1fB-2nlxA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 11 MET A 291
LEU A 292
ALA A 294
LEU A 406
LEU A 251
 None
 1.17A 4zn7B-2nlxA:
undetectable		 4zn7B-2nlxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 HIS A 138
GLU A 104
TRP A 134
 None
 1.14A 5odqD-2nlxA:
undetectable		 5odqD-2nlxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 HIS A 138
GLU A 104
TRP A 134
 None
 1.22A 5odrD-2nlxA:
undetectable		 5odrD-2nlxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		3 / 3 TYR A 371
ALA A 464
TYR A 465
 None
 0.77A 5uunB-2nlxA:
undetectable		 5uunB-2nlxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 205
ASP A 167
ASP A 170
LEU A 431
ALA A 428
 None
 0.95A 6bq4A-2nlxA:
undetectable		 6bq4A-2nlxA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 205
ASP A 167
ASP A 170
LEU A 431
ALA A 428
 None
 0.98A 6bq4B-2nlxA:
undetectable		 6bq4B-2nlxA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2nlx XYLULOSE KINASE
(Escherichia
coli) 		5 / 12 GLU A 204
HIS A 279
VAL A 262
GLU A 264
GLY A 265
 None
 1.43A 6gngA-2nlxA:
undetectable		 6gngA-2nlxA:
23.24