SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		5 / 10 ALA A 190
LEU A 187
PHE A 177
PHE A 195
LEU A 121
 None
 1.19A 1y7iB-2nmbA:
undetectable		 1y7iB-2nmbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		6 / 12 LEU A 121
GLY A 192
ALA A 190
ASP A  72
GLY A 184
VAL A  85
 None
 1.15A 2ienA-2nmbA:
undetectable		 2ienA-2nmbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		5 / 10 VAL A  76
VAL A 123
LEU A 121
GLY A 125
GLY A 127
 None
 1.30A 3ls4H-2nmbA:
undetectable		 3ls4H-2nmbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		5 / 10 GLY A 192
ALA A 190
ASP A  72
GLY A 184
VAL A  85
 None
 0.98A 3oxwA-2nmbA:
undetectable		 3oxwA-2nmbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		5 / 10 GLY A 192
ALA A 190
ASP A  72
GLY A 184
VAL A  85
 None
 1.01A 3oxwC-2nmbA:
undetectable		 3oxwC-2nmbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		3 / 3 ASP A 182
GLU A 157
GLY A 159
 None
 0.60A 3w9tA-2nmbA:
undetectable		 3w9tA-2nmbA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2nmb PROTEIN (NUMB
PROTEIN)
(Drosophila
melanogaster) 		5 / 12 SER A 112
GLY A 176
GLY A  89
VAL A 108
LEU A 106
 None
 0.99A 5kocB-2nmbA:
undetectable		 5kocB-2nmbA:
17.11