SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 12 ILE A 140
LEU A 184
VAL A 135
ALA A 146
ILE A 108
 None
 1.04A 1epbB-2nmpA:
undetectable		 1epbB-2nmpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 12 LEU A 302
GLN A 306
MET A 191
THR A 315
ILE A 290
 None
 1.35A 1p93A-2nmpA:
undetectable		 1p93A-2nmpA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 12 LEU A 259
LEU A  78
ALA A  74
LEU A 224
MET A 222
 None
 1.40A 2aa6A-2nmpA:
undetectable		 2aa6A-2nmpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 SER A 226
SER A 206
ASN A 188
GLN A 196
 None
 1.12A 2cmlA-2nmpA:
undetectable		 2cmlA-2nmpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 8 SER A 226
SER A 206
ASN A 188
GLN A 196
 None
 1.15A 2cmlD-2nmpA:
undetectable		 2cmlD-2nmpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 LEU A 337
LEU A 332
GLU A 349
MET A 354
 None
 1.30A 2kuhA-2nmpA:
0.0		 2kuhA-2nmpA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 ILE A  41
LEU A  43
LEU A 254
ASP A 251
 None
 1.02A 2rlfA-2nmpA:
undetectable
2rlfD-2nmpA:
undetectable		 2rlfA-2nmpA:
8.84
2rlfD-2nmpA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 9 LEU A 329
LEU A 376
ALA A 393
LEU A 390
PHE A 316
 None
 1.27A 2vcvH-2nmpA:
undetectable		 2vcvH-2nmpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 12 ILE A 182
PHE A  18
ALA A  22
ALA A  74
LEU A 224
 None
 1.28A 2x2nD-2nmpA:
undetectable		 2x2nD-2nmpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 10 LEU A 232
LEU A 100
SER A 242
LEU A 239
ARG A 237
 None
 1.04A 2xn7A-2nmpA:
undetectable
2xn7B-2nmpA:
undetectable		 2xn7A-2nmpA:
20.79
2xn7B-2nmpA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.03A 3asnP-2nmpA:
undetectable
3asnW-2nmpA:
undetectable		 3asnP-2nmpA:
20.25
3asnW-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.02A 3asoP-2nmpA:
undetectable
3asoW-2nmpA:
undetectable		 3asoP-2nmpA:
20.25
3asoW-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 5 TYR A 208
ALA A 203
ALA A  76
TYR A  83
 None
 1.25A 3d91A-2nmpA:
undetectable		 3d91A-2nmpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 THR A  98
ILE A 132
SER A 126
LEU A 130
 None
 0.88A 3deuB-2nmpA:
undetectable		 3deuB-2nmpA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 GLY A 202
ALA A 203
ASP A 204
ILE A 175
 None
 0.77A 3t3cA-2nmpA:
undetectable		 3t3cA-2nmpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 VAL A 221
SER A  89
THR A 211
GLY A  90
 PLP  A 500 ( 4.8A)
PLP  A 500 (-3.6A)
PLP  A 500 (-3.2A)
PLP  A 500 (-3.5A)
 1.15A 3tj7C-2nmpA:
undetectable
3tj7D-2nmpA:
undetectable		 3tj7C-2nmpA:
19.45
3tj7D-2nmpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 10 ILE A 132
VAL A 124
PHE A 121
ILE A  97
ILE A 107
 None
 1.24A 3um5A-2nmpA:
undetectable		 3um5A-2nmpA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 10 ILE A 132
VAL A 124
PHE A 121
ILE A  97
ILE A 107
 None
 1.26A 3um5B-2nmpA:
undetectable		 3um5B-2nmpA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 CYH A 229
ASN A 228
ASP A 204
ILE A 183
 None
 1.49A 3w9tB-2nmpA:
undetectable		 3w9tB-2nmpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.04A 3wg7P-2nmpA:
undetectable
3wg7W-2nmpA:
undetectable		 3wg7P-2nmpA:
20.25
3wg7W-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 8 GLY A 202
ALA A 203
ASP A 204
THR A 158
 None
 0.47A 4eyrB-2nmpA:
undetectable		 4eyrB-2nmpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 GLY A 202
ASN A 228
GLU A 170
ILE A 169
 None
 0.96A 4fglD-2nmpA:
2.3		 4fglD-2nmpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 ASP A 111
GLY A 368
PRO A 351
THR A 355
 None
 0.95A 4l1aB-2nmpA:
undetectable		 4l1aB-2nmpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 THR A 163
ILE A 369
THR A 355
GLY A 115
 None
 0.96A 4l39B-2nmpA:
undetectable		 4l39B-2nmpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 8 SER A 138
ASP A 136
GLN A 299
THR A 163
 None
 1.16A 4lnwA-2nmpA:
undetectable		 4lnwA-2nmpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 8 LYS A  73
ALA A  74
LEU A  78
LEU A 259
 None
 0.85A 4po0A-2nmpA:
undetectable		 4po0A-2nmpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 PRO A 198
ILE A 167
VAL A 176
ARG A 305
 None
 1.12A 4xe5A-2nmpA:
1.8		 4xe5A-2nmpA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		3 / 3 VAL A  25
PHE A  18
ARG A 197
 None
 0.77A 4xr4B-2nmpA:
2.4		 4xr4B-2nmpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		5 / 9 VAL A 276
VAL A 314
ILE A 374
PHE A 328
LEU A 390
 None
 1.47A 5e4dA-2nmpA:
undetectable		 5e4dA-2nmpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 4 SER A  89
ALA A  92
GLN A 240
THR A  96
 PLP  A 500 (-3.6A)
None
None
None
 1.42A 5n0wA-2nmpA:
2.1		 5n0wA-2nmpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 6 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.03A 5x19P-2nmpA:
undetectable		 5x19P-2nmpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 5 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.04A 5x1bP-2nmpA:
undetectable		 5x1bP-2nmpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 7 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.04A 5x1fP-2nmpA:
undetectable
5x1fW-2nmpA:
undetectable		 5x1fP-2nmpA:
20.25
5x1fW-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens) 		4 / 8 ILE A 290
THR A 163
THR A 158
SER A 138
 None
 1.08A 6c06C-2nmpA:
0.0		 6c06C-2nmpA:
undetectable