SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 THR C 245
ALA C 243
LEU C  89
LEU C  96
LEU C 253
 None
 1.29A 1eiiA-2nn3C:
undetectable		 1eiiA-2nn3C:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 8 GLY C 168
ALA C 160
ALA C 167
PHE C 210
HIS C 207
 None
 1.07A 2ha4A-2nn3C:
3.6		 2ha4A-2nn3C:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.29A 2pnjB-2nn3C:
3.1		 2pnjB-2nn3C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.16A 2po5A-2nn3C:
2.7		 2po5A-2nn3C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.19A 2po7A-2nn3C:
3.0		 2po7A-2nn3C:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.23A 2po7B-2nn3C:
3.1		 2po7B-2nn3C:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.29A 3aqiB-2nn3C:
undetectable		 3aqiB-2nn3C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 5 ILE C  65
THR C 118
PHE C 158
PHE C 173
 None
 1.32A 3em0A-2nn3C:
undetectable		 3em0A-2nn3C:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 11 LEU C 142
VAL C 133
ALA C 132
PHE C 173
PHE C 210
 None
 1.38A 3n23C-2nn3C:
2.2		 3n23C-2nn3C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.24A 3w1wA-2nn3C:
3.1		 3w1wA-2nn3C:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.29A 3w1wB-2nn3C:
undetectable		 3w1wB-2nn3C:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 9 ALA C 144
LEU C 154
LEU C 142
LEU C 134
ILE C 175
 None
 1.18A 3wdmC-2nn3C:
3.7		 3wdmC-2nn3C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 6 GLN C 234
ARG C 241
ASP C  85
GLN C 176
 None
 1.40A 4azvA-2nn3C:
2.9		 4azvA-2nn3C:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		3 / 3 GLU C  69
GLY C  81
SER C  78
 None
 0.60A 4b53B-2nn3C:
undetectable		 4b53B-2nn3C:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 VAL C 131
THR C 159
ILE C 115
PHE C 158
TRP C 155
 None
 1.28A 4c49A-2nn3C:
undetectable		 4c49A-2nn3C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		5 / 12 VAL C 131
THR C 159
ILE C 115
PHE C 158
TRP C 155
 None
 1.29A 4c49C-2nn3C:
undetectable		 4c49C-2nn3C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 7 ASN C 112
GLU C 110
ILE C 111
ASP C 146
 None
 1.10A 4d39B-2nn3C:
undetectable		 4d39B-2nn3C:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 7 PHE C 173
PHE C 158
THR C 118
ILE C 115
 None
 0.91A 4ejjA-2nn3C:
undetectable		 4ejjA-2nn3C:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 8 LEU C 240
VAL C  92
LEU C 211
LEU C 172
 None
 0.96A 4l1xA-2nn3C:
undetectable		 4l1xA-2nn3C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		4 / 8 LEU C 240
MET C  55
LEU C 291
ILE C 212
 None
 0.94A 4ok1A-2nn3C:
undetectable		 4ok1A-2nn3C:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2nn3 CASPASE-1
(Spodoptera
frugiperda) 		3 / 3 ALA C 268
PHE C 264
GLN C 279
 None
 0.77A 6eceA-2nn3C:
3.3		 6eceA-2nn3C:
21.49