SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RAE_F_LFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	2nox	TRYPTOPHAN 2,3-DIOXYGENASE (Cupriavidus metallidurans)	3 / 4	SER A 109 GLY A 240 GLU A 291	None	0.61A	3raeA-2noxA: undetectable 3raeC-2noxA: undetectable	3raeA-2noxA: 20.24 3raeC-2noxA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA603_1 (SERUM ALBUMIN)	2nox	TRYPTOPHAN 2,3-DIOXYGENASE (Cupriavidus metallidurans)	5 / 11	LEU A 86 ARG A 90 LEU A 288 LEU A 83 LEU A 246	None	1.23A	4or0A-2noxA: undetectable	4or0A-2noxA: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YIA_B_IMNB401_2 (THYROXINE-BINDING GLOBULIN)	2nox	TRYPTOPHAN 2,3-DIOXYGENASE (Cupriavidus metallidurans)	3 / 3	LEU A 86 ARG A 87 ARG A 90	None	0.88A	4yiaB-2noxA: undetectable	4yiaB-2noxA: 12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U6M_B_SALB503_1 (UDP-GLYCOSYLTRANSFER ASE 74F2)	2nox	TRYPTOPHAN 2,3-DIOXYGENASE (Cupriavidus metallidurans)	4 / 7	HIS A 72 PHE A 68 MET A 133 THR A 271	HEM A 500 (-3.5A) HEM A 500 (-4.4A) None None	1.28A	5u6mB-2noxA: undetectable	5u6mB-2noxA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U6N_A_SALA505_1 (UDP-GLYCOSYLTRANSFER ASE 74F2)	2nox	TRYPTOPHAN 2,3-DIOXYGENASE (Cupriavidus metallidurans)	4 / 8	HIS A 72 PHE A 68 MET A 133 THR A 271	HEM A 500 (-3.5A) HEM A 500 (-4.4A) None None	1.27A	5u6nA-2noxA: undetectable	5u6nA-2noxA: 21.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3RAE_F_LFXF101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","2nox","TRYPTOPHAN 2,3-DIOXYGENASE","Cupriavidus metallidurans",3,"SER A 109;GLY A 240;GLU A 291","None","0.61A","3raeA-2noxA:undetectable;3raeC-2noxA:undetectable","3raeA-2noxA:20.24;3raeC-2noxA:22.40"],["4OR0_A_NPSA603_1","SERUM ALBUMIN","2nox","TRYPTOPHAN 2,3-DIOXYGENASE","Cupriavidus metallidurans",5,"LEU A  86;ARG A  90;LEU A 288;LEU A  83;LEU A 246","None","1.23A","4or0A-2noxA:undetectable","4or0A-2noxA:18.87"],["4YIA_B_IMNB401_2","THYROXINE-BINDING GLOBULIN","2nox","TRYPTOPHAN 2,3-DIOXYGENASE","Cupriavidus metallidurans",3,"LEU A  86;ARG A  87;ARG A  90","None","0.88A","4yiaB-2noxA:undetectable","4yiaB-2noxA:12.04"],["5U6M_B_SALB503_1","UDP-GLYCOSYLTRANSFERASE 74F2","2nox","TRYPTOPHAN 2,3-DIOXYGENASE","Cupriavidus metallidurans",4,"HIS A  72;PHE A  68;MET A 133;THR A 271","HEM A 500 (-3.5A);HEM A 500 (-4.4A);None;None","1.28A","5u6mB-2noxA:undetectable","5u6mB-2noxA:21.92"],["5U6N_A_SALA505_1","UDP-GLYCOSYLTRANSFERASE 74F2","2nox","TRYPTOPHAN 2,3-DIOXYGENASE","Cupriavidus metallidurans",4,"HIS A  72;PHE A  68;MET A 133;THR A 271","HEM A 500 (-3.5A);HEM A 500 (-4.4A);None;None","1.27A","5u6nA-2noxA:undetectable","5u6nA-2noxA:21.92"]]