SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2np3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2np3 PUTATIVE TETR-FAMILY
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A 103
GLY A 104
GLY A 201
VAL A 169
ALA A 206
 None
 1.12A 1nv8A-2np3A:
undetectable		 1nv8A-2np3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2np3 PUTATIVE TETR-FAMILY
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLU A  83
LEU A 124
THR A  37
LYS A  35
 None
 1.16A 1rmtB-2np3A:
undetectable		 1rmtB-2np3A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2np3 PUTATIVE TETR-FAMILY
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ILE A 103
GLY A 104
GLY A 201
VAL A 169
ALA A 206
 None
 1.02A 1vq1B-2np3A:
undetectable		 1vq1B-2np3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2np3 PUTATIVE TETR-FAMILY
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLY A 201
ILE A  92
ALA A 152
VAL A 169
ILE A 157
 None
 1.15A 2nnhA-2np3A:
undetectable		 2nnhA-2np3A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2np3 PUTATIVE TETR-FAMILY
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 VAL A 128
ALA A 138
PHE A  78
 None
 0.85A 4olbA-2np3A:
undetectable		 4olbA-2np3A:
13.49