SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2np5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 11 LEU A  61
LEU A 154
MET A 106
LEU A  68
ILE A 130
 None
None
None
None
LMT  A 204 ( 4.8A)
 1.38A 1ee2B-2np5A:
undetectable		 1ee2B-2np5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 LEU A  93
PRO A  94
LEU A 176
 None
 0.55A 1hrkA-2np5A:
undetectable		 1hrkA-2np5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 LEU A 152
LEU A 134
ALA A  88
MET A  89
GLN A 183
 None
LMT  A 204 ( 4.8A)
LMT  A 204 (-3.5A)
None
None
 1.25A 1kt4A-2np5A:
undetectable		 1kt4A-2np5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 GLU A 147
ARG A 131
ILE A 187
ARG A 149
GLU A 145
 None
 1.47A 1l7fA-2np5A:
undetectable		 1l7fA-2np5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 GLU A 147
ARG A 131
ILE A 187
ARG A 149
GLU A 145
 None
 1.50A 1l7hA-2np5A:
undetectable		 1l7hA-2np5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 LEU A  93
PRO A  94
LEU A 176
 None
 0.34A 2qd5B-2np5A:
undetectable		 2qd5B-2np5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
 None
 1.10A 2y7kC-2np5A:
undetectable		 2y7kC-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
 None
 1.10A 2y7kD-2np5A:
undetectable		 2y7kD-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
 None
 1.23A 2y7pA-2np5A:
undetectable		 2y7pA-2np5A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 THR A 143
ILE A 141
GLY A 142
GLY A 190
PRO A  81
 None
 1.10A 2y7wB-2np5A:
undetectable		 2y7wB-2np5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		3 / 3 LEU A  93
PRO A  94
LEU A 176
 None
 0.44A 3w1wB-2np5A:
undetectable		 3w1wB-2np5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 GLU A 147
ARG A 131
ILE A 187
ARG A 149
GLU A 145
 None
 1.46A 4mwvA-2np5A:
undetectable		 4mwvA-2np5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2np5 TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 LEU A 188
LEU A 153
ILE A 141
SER A 135
GLY A 140
 None
 1.09A 6dm0B-2np5A:
undetectable
6dm0C-2np5A:
undetectable		 6dm0B-2np5A:
17.73
6dm0C-2np5A:
17.73