SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2npm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SFU_C_RBVC601_1 (RNA POLYMERASE)	2npm	14-3-3 DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	5 / 11	ARG A 84 LEU A 120 LEU A 128 GLY A 153 ASP A 154	None	1.38A	3sfuC-2npmA: undetectable	3sfuC-2npmA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ALC_L_TIQL1210_2 (ANTI-TICAGRELOR FAB 72, LIGHT CHAIN)	2npm	14-3-3 DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 8	SER A 160 ILE A 127 GLY A 153 PHE A 206	None	0.82A	5alcL-2npmA: undetectable	5alcL-2npmA: 19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5JM4_A_BEZA301_0 (14-3-3 PROTEIN ZETA/DELTA)	2npm	14-3-3 DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 5	PHE A 225 ILE A 229 MET A 247 GLN A 248	None	0.49A	5jm4A-2npmA: 32.1	5jm4A-2npmA: 55.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5M35_A_BEZA302_0 (14-3-3 PROTEIN ZETA/DELTA)	2npm	14-3-3 DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 5	PHE A 225 THR A 244 MET A 247 GLN A 248	None	0.38A	5m35A-2npmA: 32.8	5m35A-2npmA: 58.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3SFU_C_RBVC601_1","RNA POLYMERASE","2npm","14-3-3 DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",5,"ARG A  84;LEU A 120;LEU A 128;GLY A 153;ASP A 154","None","1.38A","3sfuC-2npmA:undetectable","3sfuC-2npmA:20.00"],["5ALC_L_TIQL1210_2","ANTI-TICAGRELOR FAB 72, LIGHT CHAIN","2npm","14-3-3 DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"SER A 160;ILE A 127;GLY A 153;PHE A 206","None","0.82A","5alcL-2npmA:undetectable","5alcL-2npmA:19.39"],["5JM4_A_BEZA301_0","14-3-3 PROTEIN ZETA\/DELTA","2npm","14-3-3 DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"PHE A 225;ILE A 229;MET A 247;GLN A 248","None","0.49A","5jm4A-2npmA:32.1","5jm4A-2npmA:55.77"],["5M35_A_BEZA302_0","14-3-3 PROTEIN ZETA\/DELTA","2npm","14-3-3 DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"PHE A 225;THR A 244;MET A 247;GLN A 248","None","0.38A","5m35A-2npmA:32.8","5m35A-2npmA:58.00"]]