SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2npn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		4 / 7 LEU A  34
PHE A 106
VAL A 108
VAL A   6
 None
 0.72A 1epbA-2npnA:
undetectable		 1epbA-2npnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 LEU A  34
PHE A 106
VAL A 108
VAL A   6
 None
 0.67A 1epbB-2npnA:
undetectable		 1epbB-2npnA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		7 / 9 LEU A 114
TYR A 115
THR A 142
ALA A 143
LEU A 185
LEU A 147
THR A 243
 SAM  A4633 (-4.1A)
None
SAM  A4633 (-4.0A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.2A)
None
SAM  A4633 (-3.9A)
 1.50A 2npnA-2npnA:
39.8		 2npnA-2npnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		6 / 9 THR A  11
GLY A  10
THR A 142
ALA A 143
LEU A 207
THR A 243
 SAM  A4633 (-4.4A)
None
SAM  A4633 (-4.0A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
 1.13A 2npnA-2npnA:
39.8		 2npnA-2npnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		9 / 9 THR A  11
GLY A 110
LEU A 114
TYR A 115
THR A 142
ALA A 143
LEU A 185
LEU A 207
THR A 243
 SAM  A4633 (-4.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.1A)
None
SAM  A4633 (-4.0A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
 0.00A 2npnA-2npnA:
39.8		 2npnA-2npnA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 10 TYR A  61
ILE A   4
ALA A  30
VAL A   6
LEU A  34
 None
 1.38A 3ay0A-2npnA:
undetectable		 3ay0A-2npnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		3 / 3 LEU A 207
MET A 241
ASP A 186
 SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
None
 0.73A 3v5wA-2npnA:
undetectable		 3v5wA-2npnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 242
GLY A 187
TYR A 244
 None
 0.80A 3w9tC-2npnA:
undetectable		 3w9tC-2npnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 242
GLY A 187
TYR A 244
 None
 0.79A 3w9tG-2npnA:
undetectable		 3w9tG-2npnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 11 ILE A 121
THR A 118
LEU A  34
VAL A  63
LEU A  90
 None
 1.14A 4g1bB-2npnA:
2.1		 4g1bB-2npnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 9 ILE A 121
THR A 118
LEU A  34
VAL A  63
LEU A  90
 None
 1.08A 4g1bC-2npnA:
2.1		 4g1bC-2npnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 121
THR A 118
LEU A  34
VAL A  63
LEU A  90
 None
 1.15A 4g1bD-2npnA:
2.1		 4g1bD-2npnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 10 LEU A  34
PHE A 106
ARG A  86
ALA A  87
PRO A 112
 None
 1.29A 5m0oA-2npnA:
undetectable		 5m0oA-2npnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 MET A 125
ALA A 133
PHE A 106
LEU A  34
VAL A  32
 None
 0.94A 5tudA-2npnA:
undetectable		 5tudA-2npnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 MET A 125
ALA A 133
PHE A 106
LEU A  34
VAL A  32
 None
 0.94A 5tudD-2npnA:
undetectable		 5tudD-2npnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 214
GLY A 204
ILE A 240
VAL A 226
LEU A 229
 None
 1.04A 6ectA-2npnA:
undetectable		 6ectA-2npnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 214
GLY A 204
ILE A 240
VAL A 226
LEU A 229
 None
 0.98A 6ecxA-2npnA:
undetectable		 6ecxA-2npnA:
21.97