SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2nps SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  99
LEU A 106
VAL D 225
VAL D 218
 None
 1.12A 1e7aB-2npsA:
undetectable		 1e7aB-2npsA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2nps SYNTAXIN-6
(Homo
sapiens) 		4 / 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.81A 1fbmB-2npsD:
3.9		 1fbmB-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2nps SYNTAXIN-6
(Homo
sapiens) 		4 / 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.65A 1fbmD-2npsD:
undetectable		 1fbmD-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2nps SYNTAXIN-6
(Homo
sapiens) 		4 / 5 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.71A 1fbmE-2npsD:
3.8		 1fbmE-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2nps VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
SYNTAXIN 13
SYNTAXIN-6
(Mus
musculus;
Rattus
norvegicus;
Homo
sapiens) 		5 / 12 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.11A 1jolA-2npsB:
undetectable		 1jolA-2npsB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 ILE B 216
ILE C 160
MET D 200
GLN D 197
GLU B 220
 None
 1.37A 1ki3B-2npsB:
undetectable		 1ki3B-2npsB:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2nps SYNTAXIN-6
(Homo
sapiens) 		4 / 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.65A 1mz9D-2npsD:
4.1		 1mz9D-2npsD:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.17A 1tdrA-2npsB:
undetectable		 1tdrA-2npsB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 ALA B 241
LEU D 222
LEU B 237
LEU A 106
ARG A 107
 None
 1.03A 2xn6A-2npsB:
undetectable
2xn6B-2npsB:
undetectable		 2xn6A-2npsB:
13.36
2xn6B-2npsB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 2nps VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
SYNTAXIN 13
SYNTAXIN-6
(Mus
musculus;
Rattus
norvegicus;
Homo
sapiens) 		5 / 12 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.22A 2zzaA-2npsB:
undetectable		 2zzaA-2npsB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.11A 3ia4B-2npsB:
undetectable		 3ia4B-2npsB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2nps VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
SYNTAXIN-6
(Mus
musculus;
Rattus
norvegicus;
Homo
sapiens) 		4 / 6 ASP C 171
LEU C 167
ALA A  96
LEU D 215
 None
 0.95A 3rozA-2npsC:
undetectable		 3rozA-2npsC:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2nps SYNTAXIN 13
VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Mus
musculus;
Rattus
norvegicus) 		5 / 11 LEU A  92
GLU B 224
THR C 170
HIS B 229
VAL B 230
 None
 1.15A 4e0fA-2npsA:
undetectable		 4e0fA-2npsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 11 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.18A 4qi9C-2npsB:
undetectable		 4qi9C-2npsB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2nps SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus) 		3 / 3 ASP A  52
VAL A  57
LEU D 173
 None
 0.67A 5e5jB-2npsA:
undetectable		 5e5jB-2npsA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2nps SYNTAXIN 13
SYNTAXIN-6
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 4
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 ILE B 195
ALA B 193
ILE A  54
ARG A  50
LEU D 173
 None
 1.14A 5hi6B-2npsB:
undetectable		 5hi6B-2npsB:
17.96