SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2nq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		5 / 11 SER A  77
LEU A  79
LEU A 142
VAL A  47
ILE A  72
 None
 1.18A 1ee2B-2nq3A:
undetectable		 1ee2B-2nq3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 6 THR A 131
LEU A 122
GLY A 124
LYS A  30
 None
 1.29A 1gtiC-2nq3A:
undetectable		 1gtiC-2nq3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 8 THR A  60
THR A  54
VAL A  83
VAL A  43
 None
 0.84A 1t86A-2nq3A:
undetectable		 1t86A-2nq3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		5 / 12 LEU A 142
GLY A 141
LEU A 113
ILE A 102
LEU A  79
 None
 0.96A 3gwvA-2nq3A:
undetectable		 3gwvA-2nq3A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 5 GLY A  96
ASP A 125
ARG A  82
GLN A  87
 None
 1.38A 3qx3B-2nq3A:
undetectable		 3qx3B-2nq3A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 8 HIS A  80
ASP A  48
ASP A 101
ILE A 102
 None
 1.02A 4k0bA-2nq3A:
undetectable		 4k0bA-2nq3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 8 HIS A  80
ASP A  48
ASP A 101
ILE A 102
 None
 1.06A 4l7iA-2nq3A:
undetectable		 4l7iA-2nq3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		5 / 12 LEU A 106
SER A 108
LEU A 142
LEU A  79
ILE A 102
 None
 1.09A 4x1fA-2nq3A:
undetectable		 4x1fA-2nq3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		5 / 12 LEU A 106
SER A 108
LEU A 142
LEU A  79
ILE A 102
 None
 1.09A 4x1gA-2nq3A:
undetectable		 4x1gA-2nq3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 7 VAL A 118
LEU A 120
LEU A 139
LEU A 113
 None
 0.57A 5jq7A-2nq3A:
undetectable		 5jq7A-2nq3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		5 / 12 LEU A 122
LEU A  29
ALA A  27
LEU A  69
TYR A  42
 None
 1.05A 5ljeA-2nq3A:
undetectable		 5ljeA-2nq3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		3 / 3 THR A  60
THR A  54
LEU A 135
 None
 0.55A 5m66D-2nq3A:
undetectable		 5m66D-2nq3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens) 		4 / 5 VAL A 116
LEU A 100
VAL A  45
LEU A 135
 None
CL  A 156 ( 4.8A)
None
None
 0.97A 6bqgA-2nq3A:
undetectable		 6bqgA-2nq3A:
14.86